Safety and Success of Repeat Lung Needle Biopsies in Patients with Epidermal Growth Factor Receptor‐Mutant Lung Cancer

AbstractBackground.Postprogression repeat biopsies are critical in caring for patients with lung cancer with epidermal growth factor receptor (EGFR) mutations. However, hesitation about invasive procedures persists. We assessed safety and tissue adequacy for molecular profiling among repeat postprogression percutaneous transthoracic needle aspirations and biopsies (rebiopsies).Materials and Methods.All lung biopsies performed at our hospital from 2009 to 2017 were reviewed. Complications were classified by Society of Interventional Radiology criteria. Complication rates between rebiopsies in EGFR‐mutants and all other lung biopsies (controls) were compared using Fisher's exact test. Success of molecular profiling was recorded.Results.During the study period, nine thoracic radiologists performed 107 rebiopsies in 75 EGFR‐mutant patients and 2,635 lung biopsies in 2,347 patients for other indications. All biopsies were performed with computed tomography guidance, coaxial technique, and rapid on‐site pathologic evaluation (ROSE). The default procedure was to take 22‐gauge fine‐needle aspirates (FNA) followed by 20‐gauge tissue cores. Minor complications occurred in 9 (8.4%) rebiopsies and 503 (19.1%; p = .004) controls, including pneumothoraces not requiring chest tube placement (4 [3.7%] vs. 426 [16.2%] in rebiopsies and controls, respectively; p
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Lung Cancer, Cancer Diagnostics and Molecular Pathology Source Type: research