The Effect of Traumatic-like Stress Exposure on Alterations in the Temporal Social Behavior of a Rodent Population.

The Effect of Traumatic-like Stress Exposure on Alterations in the Temporal Social Behavior of a Rodent Population. Stress. 2019 Dec 09;:1-45 Authors: Han M, Luo H, Bai Y, Zheng S, Li F, Fu J, Jiang S, Liu Z, Zheng X Abstract Though the relationship between traumatic stress and social behavior, which has been explored for years, is dynamic and largely estimated between dyads, little is known about the causal effects of traumatic stress exposure on the time-dependent dynamic alterations in the social behaviors on a large-group level. We thus investigated the effect of a single prolonged stress (SPS) exposure, a classical animal model that recapitulates posttraumatic stress disorder (PTSD)-like symptoms in rodents, on the spatiotemporal, social behavior changes within a large group of cohabiting rats. One-half of thirty-two Sprague-Dawley rats were assigned to the experimental group and subjected to SPS treatment administered two weeks after baseline social behavior recording; the other half served as the controls. Each group of rats (nā€‰=ā€‰16) was housed in one of two large custom-made cylinders. We used an automatic tracking system to record the behavioral indices of social behavior of the rats before SPS exposure, on the SPS exposure day, during a 7-day-long quiescent period after SPS treatment, as well as during subsequent behavioral test days. In addition to SPS-induced PTSD-like behaviors, SPS induced a time-dependent, oscillat...
Source: Stress - Category: Research Tags: Stress Source Type: research