Xiaoyaosan Ameliorates Chronic Immobilization Stress-Induced Depression-Like Behaviors and Anorexia in Rats: The Role of the Nesfatin-1 –Oxytocin–Proopiomelanocortin Neural Pathway in the Hypothalamus

Conclusion: Xiaoyaosan ameliorates CIS-induced depression-like behaviors and anorexia by regulating the NES1-OT-POMC neural pathway in the hypothalamus.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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CONCLUSIONS: Our results suggest that pregnancy and early life are vulnerable developmental periods when exposures may influence offspring mental health, including eating disorder risk, later in life. The results suggest that some events pose more global transdiagnostic risk whereas other patterns, such as increasing parental ages, appear more specific to EDs. PMID: 31910913 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
Advanced cancer patients are at an increased risk of developing depressive symptoms, which can lead to major depressive disorder and a poor quality of life. It is important that symptoms of depression to be addressed early and frequently throughout the trajectory of the disease process. Depression is underdiagnosed and therefore undertreated in advanced cancer patients. Clinicians often fail to perform regular depression screenings as recommended by the National Comprehensive Cancer Network. Depressive symptoms are overlooked as they tend to overlap with the effects of disease progression and cancer treatments. Patients' c...
Source: Journal of Hospice and Palliative Nursing - Category: Nursing Tags: Symptom Management Series Source Type: research
SummaryPreclinical studies suggest that histone deacetylase (HDAC) inhibitors may restore tumor sensitivity to retinoids and have synergistic anti-tumor activity when combined. We performed a Phase I clinical trial to evaluate the safety and preliminary efficacy of combining the oral HDAC inhibitor vorinostat and isotretinoin in patients with advanced renal cell carcinoma (RCC). Vorinostat was administered at 300  mg orally twice daily in combination with escalating doses of isotretinoin for 3 consecutive days per week. A standard 3 + 3 dose escalation design was used. Dose limiting toxicities (DLT) were...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
Two articles published last year in theAmerican Journal of Psychiatry have been named “top stories of 2019” by the editorial board ofNEJM Journal Watch Psychiatry.“As always, we looked for high clinical relevance, balanced with solid methodology, and every study we chose focused on improving clinicians' abilities to treat patients, whether by identifying the best options or highlighting the weaknesses of some once-touted approaches,” wrote Peter Roy-Byrne , M.D., editor-in-chief ofNEJM Journal Watch Psychiatry, in a post announcing the selection of top journal articles of the year. These are theAJP ...
Source: Psychiatr News - Category: Psychiatry Tags: AJP anorexia nervosa Evelyn Attia NEJM Journal Watch Psychiatry olanzapine Peter Roy-Byrne Sidney Zisook treatment-resistant depression VAST-D Source Type: research
At first, Melanie Murphy was just following doctor’s orders. Murphy, then 19, had gained weight during a period of depression, and her doctor told her she should lose some. She went from 180 to 125 pounds in 18 months—and even when she knew it was time to stop slimming down, she couldn’t shake the need to chase a goal. Without weight loss, she needed a new target. That became finding the “perfect” diet, one that was clean and pure and would keep her healthy for years to come. At least, that was how she thought about it then. These days, she uses a different descriptor: “orthorexia,&rdquo...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Eating Disorder Source Type: news
A 15-year-old asthenic boy (38  kg, 160 cm, body mass index 14.8) presented with postprandial discomfort, nausea, and vomiting for 1 month. In addition, there were complaints of painless gross hematuria and left flank pain. Urinalysis revealed numerous isomorphic erythrocytes. Epigastralgia and distended abdomen were noted on p hysical examination. The boy had a history of anorexia and rapidly lost 17 kg during a 3-month period. Psychiatrists had made the diagnosis of depression and anorexia nervosa.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Images Source Type: research
In Reply We thank King and Ehrlich for their thoughtful Letter critiquing our meta-analysis that examined delay discounting as a transdiagnostic process in psychiatric disorders. In our article, we proposed that delay discounting, an index of impulsive decision-making, falls on a continuum. At the aggregate level, most disorders examined (eg, major depressive disorder, bipolar disorder, schizophrenia, borderline personality disorder, binge-eating disorder, and bulimia nervosa) exhibited steeper, more impulsive, delay discounting compared with controls, whereas people with anorexia nervosa exhibited shallower, less impulsiv...
Source: JAMA Psychiatry - Category: Psychiatry Source Type: research
To the Editor Amlung and colleagues published a meta-analysis of delay discounting (DD), a behavioral measure of impulsivity and self-control, including 57 effect sizes from 43 studies across 8 psychiatric diagnostic categories. Results indicated a greater preference for smaller immediate monetary rewards (ie, more impulsive decision-making) in 6 conditions (major depression, schizophrenia, bipolar disorder, borderline personality disorder, bulimia nervosa, and binge-eating disorder) compared with controls but greater preference for larger delayed rewards (ie, more self-controlled choice) in anorexia nervosa. The findings ...
Source: JAMA Psychiatry - Category: Psychiatry Source Type: research
Publication date: 12 December 2019Source: Cell, Volume 179, Issue 7Author(s): Cross-Disorder Group of the Psychiatric Genomics ConsortiumSummaryGenetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette synd...
Source: Cell - Category: Cytology Source Type: research
Conclusion: This study shows that a specialized inpatient program for adolescents with severe EDs that was created using the principles of FBT results in positive short-term medical and psychological improvements as evidenced by improved weight gain and decreased markers of psychological distress.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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