Candida palmioleophila isolation in Italy from two cases of systemic infection, after a CHROMagar and Vitek system mis-identification as C.albicans.

Candida palmioleophila isolation in Italy from two cases of systemic infection, after a CHROMagar and Vitek system mis-identification as C.albicans. New Microbiol. 2019 Dec 09;43(1) Authors: Casagrande Pierantoni D, Bernardo M, Mallardo E, Carannante N, Attanasio V, Corte L, Roscini L, Di Fiore L, Tascini C, Cardinali G Abstract A correct, fast, reliable identification method is pivotal in nosocomial environments to guide treatment strategies, whereas misidentification might lead to treatment failure. For routine identifications the Vitek system and CHROMagar are widely used but not always reliable, especially now with an increasing number of new emerging fungal pathogens that need careful identification. Here we describe two cases of candidemia, due to Candida palmioleophila previously misidentified as Candida albicans by using the Vitek2 system and CHROMagar. The first case is a 54-year-old man with an infected ulcer in the lower right limb, treated with a targeted therapy using a central venous catheter (CVC). After two months he developed a CVC-related candidemia MDR identified as C. albicans. The second case is a 2-month-old male baby that was admitted to the neonatal unit with acute respiratory failure due to a severe community-acquired bilateral pneumonia; blood cultures were all positive for C. albicans MDR. The isolated strains where re-identified with Maldi-Tof and DNA sequencing as C. palmioleophila. From the identification point of view, CHROM...
Source: New Microbiologica - Category: Microbiology Tags: New Microbiol Source Type: research

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AbstractPurpose of ReviewThis review has incorporated the knowledge and experience of the leads of each of the laboratory working parties of the fungal PCR initiative in order to provide up-to-date information on the performance and developments of PCR methods for the detection of fungi that commonly cause invasive fungal disease (IFD).Recent FindingsMolecular diagnosis of IFD enhances the current repertoire of mycological investigations. Providing superior sensitivity and turn-around-time over classical approaches, yet maintaining the benefits of classical tests (e.g. species level identification and identifying resistanc...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
Publication date: Available online 27 December 2019Source: Inorganica Chimica ActaAuthor(s): Joshua A. Obaleye, Abiodun A. Ajibola, Van B. Bernardus, Eric C. Hosten, Andrew OzarowskiAbstractIn this work, we report the synthesis and characterization of a novel dimeric complex Cu2(μ–TCA)2(TCA)2(MET)4 [where TCA = trichloroacetic acid; MET = metronidazole]. The reaction was carried out at room temperature to obtain a blue crystalline compound. The complex was characterized by elemental analysis, electronic spectroscopy, FT–IR, High–Field EPR and X–ray crystallography. The complex crystallized in the...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Publication date: 15 March 2020Source: Journal of Molecular Structure, Volume 1204Author(s): Duygu Åžahin Gül, Hatice Ogutcu, Zeliha HayvalıAbstractTwo different series of crown ether compounds (4-11) were synthesized by the reactions of 4′,5′-bis(bromomethyl)benzo-15-crown-5 (3) and 4′-amino-benzo-15-crown-5 with hydroxycoumarin and chromone derivatives. Coumarin-crown ether compounds (4 and 5) were synthesized by the reactions of 4′,5′-bis(bromomethyl)benzo-15-crown-5 (3) with 4-hydroxycoumarin and 7-hydroxycoumarin. Chromone-crown ether compounds (6-11), were synthesized by the conden...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
We investigated the characteristics and associated factors of invasive fungal disease in patients with type  2 diabetes mellitus from Southern China for the first time. We found thatCandida albicans,Cryptococcus neoformans andAspergillus fumigatus were the leading agents. Prolonged hyperglycemia results in unfavorable outcomes. Correction of anemia and hypoalbuminemia might improve prognosis. AbstractAims/IntroductionA retrospective study was carried out to investigate the clinical characteristics and associated factors for invasive fungal disease in patients with type  2 diabetes mellitus.Materials and MethodsDe...
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: Original Article Source Type: research
ConclusionsThe presence of Candida spp airway colonization is associated with longer durations of mechanical ventilation, higher 28-day mortality, higher ICU mortality, and probably longer ICU length of stay compared with the absence of colonization in patients with VAP.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
ConclusionTheA. marmelos mediated silver nanoparticle gel had the desired physiochemical properties with greater antimicrobial activity than the marketed formulation. This in vitro study recommends the use of phytofibricated silver nanoparticle formulation over conventional antiseptic creams.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
AbstractObjectivesA retrospective study was performed to investigate the clinical characteristics and associated factors for invasive fungal disease (IFD) in patients with type 2 diabetes mellitus (T2DM).MethodsDemographic and clinical data were recorded. Associated factors were analyzed by logistic regression analysis.ResultsIFD was diagnosed in 120 patients with T2DM (prevalence, 0.4%). Yeast infection (56/120, 46.7%), including candidiasis (31/56, 55.4%) and cryptococcosis (25/56, 44.6%) was the most common. Urinary tract was mainly involved in candidiasis (12/31, 38.7%). More than half of the cryptococcosis (16/25, 64....
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Objective: to study features of pulmonary complications in intravenous drug users (IDUs) with and without HIV.Materials and Methods: 149 patients (111 were males, mean age - 34,6±5,2 years)- IDUs diagnosed with pneumonia who were included in the study as they admitted to the hospital. HIV infection was verified in 112 (75%). 105 (70%) patients had viral hepatitis (B, C, B+C), 70 (47%) -tuberculosis.Results: In the presence of HIV infection, especially with severe immunosuppression of CD4+
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research
In this study, two small peptides, RcAlb-PepI and RcAlb-PepII, were designed based on the primary structure of Rc-2S-Alb, a 2S albumin from the seed cake of Ricinus communis, and their antimicrobial activity assessed. RcAlb-PepII strongly inhibited the growth of Klebsiella pneumoniae and Candida parapsilosis, and induced morphological alterations in their cell surface. C. parapsilosis exposed to RcAlb-PepII presented higher cell membrane permeabilization and elevated content of reactive oxygen species. RcAlb-PepII also degraded and reduced the biofilm formation in C. parapsilosis and in K. pneumonia cells. Experimentally, ...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
Publication date: 5 February 2020Source: Journal of Molecular Structure, Volume 1201Author(s): Rasha A. Azzam, Galal H. Elgemeie, Rokia R. OsmanAbstractThe synthesis of novel pyrido[2,1-b]benzothiazole and pyrido[2,1-b]benzoimidazole derivatives was achieved via the reaction of N-aryl-2-cyano-3,3-bis(methylthio)acrylamide with benzothiazoleylacetonitrile and benzoimidazoleylacetonitrile, respectively, while N-substituted 2-pyridylbenzothiazole derivatives were synthesized by reacting 2-(benzo[d]thiazol-2-yl)-3-(dimethylamino)acrylonitrile with either cyanoacetamide, aryl cyanoacetamides or 2-cyano-N’-(4-substituted b...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
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