Predictors of Left Ventricular Dysfunction after Surgery for Degenerative Mitral Regurgitation

This study was performed to determine if strain can supplement the ability of left ventricular ejection fraction (LVEF) to predict post-op ventricular dysfunction in patients undergoing mitral valve (MV) surgery for degenerative mitral regurgitation (DMR).MethodsFrom 2004 to 2017, 520 patients with an LVEF> 60% underwent MV surgery (98% repair) for DMR. All patients had preoperative (pre-op), pre-discharge (pre-dsg) and follow-up (F/U) (mean 5.0±3.6 years) echocardiograms. Speckle tracking was performed in 119/520 (22.9%) patients to determine LV strain, right ventricular (RV) free-wall strain, and left atrial longitudinal strain. Multivariate logistic and Cox regression models were used in this subgroup to evaluate associations with early postoperative LV dysfunction and medium-term overall survival, respectively.ResultsMedian pre-op LVEF of the entire cohort was 65%. Based on pre-dsg echo, 449 patients (86.3%) maintained postoperative LVEF> 50%. 71 patients (13.7%) had a pre-dsg LVEF
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research

Related Links:

In this study, mouse pulmonary stem/progenitor cells (mPSCs) with capability to differentiate into type I or type II alveolar cells were used as an in vitro cell model to characterize replication and pathogenic effects of influenza viruses in PSCs. First, mPSCs and its immortalized cell line mPSCsOct4+ were shown to be susceptible to PR8, seasonal H1N1, 2009 pandemic H1N1, and H7N9 influenza viruses and can generate infectious virus particles, although with a lower virus titer, which could be attributed by the reduced vRNA replication and nucleoprotein (NP) aggregation in the cytoplasm. Nevertheless, a significant increase...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
The J.P. Morgan Healthcare conference runs every year in San Francisco, a big draw for the biotech industry, and many organizations take the opportunity to host events at the same time. Among these, the SENS Research Foundation has for the past few years hosted a pitch day in which biotech companies in the longevity industry, largely startups, present to that portion of the Bay Area investor community interested in funding the treatment of aging as a medical condition. I was there to present on progress at Repair Biotechnologies, and took some notes on the other companies as they talked about their work. Kimera Labs ...
Source: Fight Aging! - Category: Research Authors: Tags: Investment Source Type: blogs
This should become the number one priority in public health, writesDr Guru SinghExcellent article by Edward Bullmore in Journal (Inflammation is the new frontier in public health, 20 January). Unfortunately it does not fully explore the role of prevention. It is nowbeing proven that sleep plays a major role in repairing the body, and in particular the brain, especially from the ravages of inflammation. After all, why do we sleep?Inflammation is an essential part of our existence – it’s the way the body responds to an attack from without or within. Unfortunately this also causes damage in other areas, including ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Sleep Health Society & wellbeing Life and style Mindfulness Mental health Medical research Science Source Type: news
BACKGROUND: Transportation road maintenance and repair workers, or "maintainers," are exposed to hazardous and variable noise levels and often rely on hearing protection devices (HPD) to reduce noise-exposure levels. We aimed to improve upon HPD use as par...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Occupational Issues Source Type: news
Myelin is the sheathing of nerves, essential to their function. Excessive loss produces disabling and ultimately fatal conditions such as multiple sclerosis, but we all lose myelin integrity to some degree as a consequence of the damage and dysfunction of degenerative aging. This most likely contributes to cognitive decline and other age-related issues. A number of different approaches have been identified to boost the operation of the normal maintainance processes that remyelinate nerves, such as FGF21 upregulation, or increasing the size of remyelinating cell populations. Here, researchers discover another possible trigg...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Conclusion: It can be concluded that A/S similar to TGF ‑β1 is able to facilitate the chondrogenicdifferentiation of hADSCs and do not have adverse effects of TGF ‑β1. Thus, TGF‑β1 can be replacedby A/S in the field of tissue engineering.
Source: Dental Research Journal - Category: Dentistry Source Type: research
In this study, we investigated epicardial heterogeneity and the functional diversity of discrete epicardial subpopulations in the developing zebrafish heart. Single-cell RNA-sequencing uncovered three epicardial subpopulations with specific genetic programmes and distinctive spatial distribution within the developing heart. Perturbation of unique gene signatures uncovered distinct functions associated with each subpopulation and established novel epicardial roles in cell adhesion, migration, and chemotaxis as a mechanism for recruitment of leukocytes into the heart. This work elucidates the mutual spatiotemporal relationsh...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Danio rerio Source Type: research
Contributors : Ting Xie ; Dianhua JiangSeries Type : Expression profiling by arrayOrganism : Mus musculusThe successful repair and renewal of alveolar epithelial cells are critical steps in prohibiting the accumulation of myofibroblasts and deposition of extracellular matrix in pulmonary fibrogenesis. MicroRNAs (miRNAs) are multi-focal regulators involved in the lung repair process. The contribution of miRNAs to epithelial maintenance and renewal is incompletely understood. We provide evidence that miR-29c on type 2 alveolar epithelial cells (AEC2s) are important for inhibiting AEC2 apoptosis and promoting AEC2 renewal, th...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Contributors : Martin A White ; Elise Darmon ; Manuel A Lopez-Vernaza ; David LeachSeries Type : OtherOrganism : Escherichia coli K-12The effect of a site-specific DNA double-strand break on the abundance of E. coli chromosomal DNA during exponential growth was investigated by marker frequency analysis (MFA).
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Other Escherichia coli K-12 Source Type: research
In this study, a transparent and hydrolysis-resistant silicone elastomer with self-healability, reprocessability and 3D printability is facilely fabricated by successively thiol-ene UV-curing between thiol and vinyl functionalized polysiloxanes, and thermocuring between carboxyl and amido functionalized polysiloxanes. These obtained elastomers show an excellent healing efficiency of 97%, and the healing processes are repeatable for many times. Moreover, these elastomers can be repeatedly reprocessed with a recovery of 90% of virgin mechanical strengths, and the reprocessed elastomers can still repair damages with an effici...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
More News: Cardiovascular & Thoracic Surgery | Gastroschisis Repair | Men | Study