Triptolide inhibits tonsillar IgA production by upregulating FDC-SP in IgA nephropathy.

Triptolide inhibits tonsillar IgA production by upregulating FDC-SP in IgA nephropathy.
Histol Histopathol. 2019 Dec 09;:18190
Authors: Li H, Yang X, Yao G, Zhang Y, Xu Y, Cao Y, An X, Li H, Chen H, Geng J, Yuan D, Jin X, Meng H
Abstract
IgA nephropathy (IgAN) is primarily resulted of qualitative abnormality of IgA. The occurrence of IgAN is associated with affected tonsils which enhances the IgA production via IgA class switching and immuno-activation. Follicular dendritic cell-secreted protein (FDC-SP) was found to be a negative effect for IgA production in tonsil. The previous studies suggested that Triptolide might reduce IgA production by its immunosuppression role. Given this background, this study investigated the mechanisms underlying the role of Triptolide and FDC-SP in the generation of IgA and IgA class switching in tonsil of IgAN patients. Immunohistochemistry and reverse transcription-polymerase chain reaction revealed that the expression of FDC-SP was increased in the tonsils of IgAN patients with Triptolide treatment compared with those without treatment. Meanwhile, the expression of FDC-SP was negatively correlated with IgA inducing cytokines in the tonsils of IgAN patients treated with Triptolide, due to the significant decreased IgA-bearing cells. The expression of FDC-SP in tonsillar tissue was confirmed by double immunofluorescence. Importantly, Triptolide promoted FDC-SP secretion, and correlated negatively with ...

Source: Histology and Histopathology - December 10, 2019 Category: Cytology Tags: Histol Histopathol Source Type: research