HnRNP-F promotes cell proliferation by regulating TPX2 in bladder cancer.

In this study, hnRNP-F was found to be upregulated in BC tissues and cells by western blotting. The knockdown of hnRNP-F could inhibit proliferation and delay cell cycle progression in EJ and UMUC-3 cells. Mechanistically, hnRNP-F was shown to bind to Targeting protein for Xenopus kinesin-like protein 2 (TPX2) by mass spectrometry and coimmunoprecipitation. Furthermore, Pearson correlation analysis showed that the expression of hnRNP-F was positively associated with that of TPX2 in BC tissues (P
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research

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This report describes the case of a 20 years old man who was diagnosed with a mass involving the small intestine and bladder during the course of investigations for faecaluria and abdominal pain. Histopathological examination of the biopsies during cystoscopy revealed: muscle invasive transitional cell carcinoma, while the computerized tomography scan had confirmed the enterovesical fistula.The patient was traited by Radical cystectomy with extended pelvic lymph node dissection and ileocecal resection as ultimate curative treatment.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 17 January 2020Source: European UrologyAuthor(s): Andrea Necchi, Russell Madison, Daniele Raggi, Joseph M. Jacob, Gennady Bratslavsky, Oleg Shapiro, Julia A. Elvin, Jo-Anne Vergilio, Jonathan K. Killian, Nhu Ngo, Shakti Ramkissoon, Eric Severson, Amanda C. Hemmerich, Richard Huang, Siraj M. Ali, Jon H. Chung, Prasanth Reddy, Vincent A. Miller, Alexa B. Schrock, Laurie M. GayAbstractBackgroundIn patients with rare histologies of bladder cancer, including adenocarcinoma of the bladder (ACB) and squamous-cell carcinoma (SCC), there are limited standard therapy options, defining an unmet medi...
Source: European Urology - Category: Urology & Nephrology Source Type: research
CONCLUSIONS: Our small patient group suggests that BPT can be safely applied in selected cases with bladder cancer or in patients that refused radical cystectomy. PMID: 31950922 [PubMed - in process]
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research
Authors: Borgna V, Vidal I, Castillo OA Abstract OBJECTIVE: To compare peri-operative and mid-term oncological outcomes between Open radical cystectomy (ORC) and Laparoscopic radical cystectomy (LRC). METHODS: A retrospective cohort was assembled, in which 182 patients had been subjected consecutively to Radical Cystectomy (RC) for treatment of muscle-invasive bladder cancer (MIBC) between 2000 and 2010 in a single center. Two cohorts were included: ORC (n=83) and LRC (n=99). All the RCs were performed by the same surgeon. Perioperatory complications were registered according to Clavien-Dindo classification. We...
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research
Nature Reviews Urology, Published online: 17 January 2020; doi:10.1038/s41585-019-0263-6An energetic interplay between tumour and immune cells leads to metabolic competition in the tumour ecosystem, an effect that could be targeted to boost immune checkpoint inhibition. In this Review, the authors discuss cancer cell and immune cell metabolism and consider the potential therapeutic targets within these processes.
Source: Nature Reviews Urology - Category: Urology & Nephrology Authors: Source Type: research
A new analysis provides estimates of bowel, bladder, and sexual function through five years following contemporary treatments for localized prostate cancer, which may help men clarify expectations and make more informed treatment choices, the research team says.Reuters Health Information
Source: Medscape Pathology Headlines - Category: Pathology Tags: Hematology-Oncology News Source Type: news
Researchers in Spain have discovered a drug combination showing potential in treating the most difficult-to-treat type of malignant mesothelioma. Selumetinib and AZD8186, already being studied separately in clinical trials for other cancers, displayed efficacy when used in combination on mesothelioma of the sarcomatoid cell type. Researchers at the Spanish National Cancer Research Centre made the discovery during their study using mice models and human tumor cells in the laboratory. “The findings, we hope, are relevant,” Dr. Paco Real, who led the study, told The Mesothelioma Center at “We d...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Publication date: Available online 15 January 2020Source: NeurocomputingAuthor(s): Guanjin Wang, Guangquan Zhang, Kup-Sze Choi, Kin-Man Lam, Jie LuAbstractTwo dilemmas frequently occur in many real-world clinical prognoses. First, the on-hand data cannot be put entirely into the existing prediction model, since the features from new data do not perfectly match those of the model. As a result, some unique features collected from the patients in the current domain of interest might be wasted. Second, the on-hand data is not sufficient enough to learn a new prediction model. To overcome these challenges, we propose an output-...
Source: Neurocomputing - Category: Neuroscience Source Type: research
Up to 5% of bladder cancer cases in Europe could be due to exposure to disinfectants in drinking water, say researchers, who calculate that lowering levels could almost halve that number.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
More than 6,500 cases of bladder cancer diagnosed each year in Europe can be attributed to trihalomethane exposure through drinking water, researchers report.
Source: Health News - - Category: Consumer Health News Source Type: news
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