Fold-LTR-TCP: protein fold recognition based on triadic closure principle.

In this study, the protein fold recognition is treated as an information retrieval task. The Learning to Rank model (LTR) was employed to retrieve the query protein against the template proteins to find the template proteins in the same fold with the query protein in a supervised manner. The triadic closure principle (TCP) was performed on the ranking list generated by the LTR to improve its accuracy by considering the relationship among the query protein and the template proteins in the ranking list. Finally, a predictor called Fold-LTR-TCP was proposed. The rigorous test on the LE benchmark dataset showed that the Fold-LTR-TCP predictor achieved an accuracy of 73.2%, outperforming all the other competing methods. PMID: 31813954 [PubMed - as supplied by publisher]
Source: Briefings in Bioinformatics - Category: Bioinformatics Authors: Tags: Brief Bioinform Source Type: research