Deletion of Mucosa ‐Associated Lymphoid Tissue Lymphoma Translocation Protein 1 in Mouse T Cells Protects Against Development of Autoimmune Arthritis but Leads to Spontaneous Osteoporosis

ConclusionOverall, these data in murine models of RA highlight MALT ‐1 as a master regulator of T cell activation, which is relevant to the pathogenesis of autoimmune arthritis. Furthermore, these findings show that MALT‐1 deficiency can lead to spontaneous osteoporosis, which is associated with impaired Treg cell numbers.

Source: Arthritis and Rheumatology - November 27, 2019 Category: Rheumatology Authors: Elisabeth Gilis, Djoere Gaublomme, Jens Staal, Koen Venken, Maarten Dhaenens, Stijn Lambrecht, Julie Coudenys, Tine Decruy, Nadia Schryvers, Yasmine Driege, Emilie Dumas, Annelies Demeyer, Am élie De Muynck, Jolanda Hengel, Luc Van Hoorebek Tags: Original Article Source Type: research