Direct electrophysiological evidence that spreading depolarization-induced spreading depression is the pathophysiological correlate of the migraine aura and a review of the spreading depolarization continuum of acute neuronal mass injury

AbstractSpreading depolarization is observed as a large negative shift of the direct current potential, swelling of neuronal somas, and dendritic beading in the brain ’s gray matter and represents a state of a potentially reversible mass injury. Its hallmark is the abrupt, massive ion translocation between intraneuronal and extracellular compartment that causes water uptake (= cytotoxic edema) and massive glutamate release. Dependent on the tissue’s energy st atus, spreading depolarization can co-occur with different depression or silencing patterns of spontaneous activity. In adequately supplied tissue, spreading depolarization induces spreading depression of activity. In severely ischemic tissue, nonspreading depression of activity precedes spreading d epolarization. The depression pattern determines the neurological deficit which is either spreading such as in migraine aura or migraine stroke or nonspreading such as in transient ischemic attack or typical stroke. Although a clinical distinction between spreading and nonspreading focal neurologica l deficits is useful because they are associated with different probabilities of permanent damage, it is important to note that spreading depolarization, the neuronal injury potential, occurs in all of these conditions. Here, we first review the scientific basis of the continuum of spreading depolar izations. Second, we highlight the transition zone of the continuum from reversibility to irreversibility using clinical ...
Source: AGE - Category: Geriatrics Source Type: research

Related Links:

Publication date: March–April 2020Source: Journal of Applied Developmental Psychology, Volume 67Author(s): Claudine FoxAbstractThis paper reports a study that adopted age-appropriate terminology to investigate 6–11-year-old children's attitudes towards mental illness (N = 120). The study utilized a semi-structured interview technique and card selection tasks to assess the children's attitudes to individuals diagnosed with different mental illnesses (anorexia nervosa, depression and dementia). Their attitudes were measured in terms of social distance, social functioning, emotional response and trait at...
Source: Journal of Applied Developmental Psychology - Category: Child Development Source Type: research
CONCLUSIONS: PVT1 promotes proliferation, invasion, and aerobic glycolysis in glioma cells by regulating miR-140-5p. PMID: 31957841 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: LncRNA SNHG20 promotes the proliferation and inhibits the apoptosis of NSCLC cells by targeting miR-197 through the Wnt/β-catenin signaling pathway. PMID: 31957836 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
In January, 2019, seven Aboriginal children died by suicide in Australia. By March, at least 24 young Aboriginal people were reported to have taken their lives, including three children younger than 12 years. 1 Despite Australia's wealth, the health st...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
BACKGROUND: About 40,000 infertile couples visit Tu Du Hospital, Vietnam for consultation and treatment of infertility per year. Depression in infertile female patients not only influences mental wellbeing, but also affects the effectiveness of infertility...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Young Adults Source Type: news
Background: About 84% of the agriculture, fishing, and forestry occupational sector is comprised of farmers. This sector is at high risk for suicide in the United States. Recent disasters and trade upheavals may make farmers and their families more vulnera...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Occupational Issues Source Type: news
PURPOSE OF REVIEW: Bipolar disorder has the highest rate of suicide of all psychiatric conditions and is approximately 20-30 times that of the general population. The purpose of this review is to discuss findings relevant to bipolar disorder and suicide. R...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
The objective of this article is to review the current evidence for these association...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
PURPOSE OF REVIEW: To review and discuss recent advances in evidence-based interventions (EBIs) for youth suicide risk. RECENT FINDINGS: There is a growing body of research on the effectiveness of interventions targeting suicidal ideation and behavior amon...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
OBJECTIVES: To determine the incidence, risk, and timing of mortality (unnatural and natural causes) among youth seen in a pediatric emergency department (ED) for mental health concerns, compared with matched non-mental health ED controls.METHODS: ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
More News: Brain | Depression | Geriatrics | Headache | Hemorrhagic Stroke | Ischemic Stroke | Migraine | Neurology | Neuroscience | Stroke | Subarachnoid Hemorrhage | Translocation