Effect of Eurycoma longifolia Stem Extract on Uric Acid Excretion in Hyperuricemia Mice

Conclusion: Our findings revealed that EL significantly reduced blood uric acid levels, prevented pathological changes of kidney in PO induced hyperuricemia animal model, and improved renal urate transports. We partly clarified the mechanism was related to suppressing effect of URAT1 by quassinoid in EL. This study is the first to demonstrate that EL plays a role in hyperuricemia by promoting renal uric acid excretion.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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ConclusionThe present study revealed that oral administration of CM extract for 28 days, at dosage up to 1000 mg/kg did not induce toxicological damage in rats. From acute toxicity study, the median lethal dose (LD50) of the extract was estimated to be more than 5000 mg/kg.Graphical abstract
Source: Toxicology Reports - Category: Toxicology Source Type: research
The Nepalese Government has made significant progress toward the elimination of malaria. However, given the surge in the prevalence of non-communicable diseases, such as diabetes and hypertension, and the loca...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
Increasing numbers of aging individuals with chronic co-morbidities travel to regions where falciparum malaria is endemic. Non-communicable diseases are now leading risk factors for death in such countries. Th...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
Birth control pills are among the most effective ways to prevent pregnancy, but only if women faithfully take them every day. Human nature being what it is, nearly half of women admit to missing a pill at least once every three months, and, as a result, about 9% of women on oral contraception become pregnant every year. That number would almost certainly fall if women only had to remember to take the pill once a month or so. That’s why researchers at MIT and Brigham and Women’s Hospital (with support from the Gates Foundation) are trying to create a once-a-month birth control pill. In a paper published today (...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Birth Control embargoed study Reproductive Health Source Type: news
Conclusion: There were gaps in detailed knowledge on NCDs, but positive attitude towards routine primary care integrated HIV/NCDs management, showing likely support for implementation of such policy.Keywords: Non-communicable diseases, knowledge, attitude, HIV, integration.
Source: African Health Sciences - Category: African Health Source Type: research
October 31, 2019During interviews with almost 2,000 health workers and clients in Dakar, Senegal, IntraHealth International found that some 40% of health workers had not been trained to care for clients with hypertension, and 83% of clients who did not have hypertension knew no more than a single warning sign. But a 2019 evaluation reveals significant progress in under two years.The results from our 2017-2018 situational analysis uncovered gaps in hypertension care and prevention in Dakar, including insufficiencies in equipment, hypertension management skills, and patient education.Those results helped guide theBetter Hear...
Source: IntraHealth International - Category: International Medicine & Public Health Authors: Tags: Senegal Neema Noncommunicable Diseases Human Resources Management Primary Health Care Source Type: news
ConclusionsThe study showed that over half of the frequently used medicinal plants showed moderate to high mutagenicity before and after metabolism at the concentration of a 100 μg/mL. This may have implications for the safety of those who use them to manage diseases. These findings will suggest the need for an in-depth study of the mutagenic potentials of plants commonly used by indigenous people and more especially for those exhibiting high mutagenicity in this study.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
AbstractAlgeria, like all emerging countries, has been going through a health transition over the past 30  years or so, characterized by a drop in mortality rates, an increase in life expectancy and a change in the causes of death in favor of chronic non-communicable diseases. In the past, the country mainly faced infectious diseases such as typhoid, cholera and malaria. The prevalence of the latter ha s been significantly reduced thanks to the many social health and vaccination programs undertaken by the health authorities. As a result of this epidemiological transition, we are witnessing a growing increase in the in...
Source: Internal and Emergency Medicine - Category: Emergency Medicine Source Type: research
Signaling pathways of red blood cells (RBC) micromechanics regulation, which are responsible for maintaining the microcirculation, constitute an important property of RBC physiology. Selective control over these processes may serve an indispensable tool for correction of hemorheological disorders, which accompany a number of systemic diseases (diabetes mellitus I&II, arterial hypertension, malaria, etc.). Namely, activation of certain pathways involving adenylyl cyclase may provide fast adaptive regulation of RBC deformability (RBC-D). However the specific molecular conditions of intracellular signal transduction in mediat...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
AbstractThe spleen is a lymphoid organ that has been poorly studied compared to other solid organs, probably because it has been considered a useless and unnecessary part of the body. For many centuries it has been considered a mysterious organ with uncertain functions. The first descriptions of the spleen date back to ancient ages. The spleen has been considered as a reservoir of liquids, strictly linked to stomach digestion, and in different cultures, it has been linked to melancholy and sadness due to the accumulation of black bile (humoral doctrine). A detailed anatomic description was first made by Vesalius during the...
Source: Internal and Emergency Medicine - Category: Emergency Medicine Source Type: research
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