Diabetes mellitus is not independently associated with mortality in elderly patients with ST-segment elevation myocardial infarction. Insights from the Codi Infart registry

Background Diabetes mellitus predicts poorer outcomes in patients with acute coronary syndrome (ACS), but the magnitude of this association in patients at older ages remains controversial. Methods Data were extracted from the Codi Infart database. All consecutive patients with diagnosis of ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) between 2010 and 2015 were included. We assessed the impact of diabetes mellitus on 30-day and one-year mortality in patients aged less than and at least 75 years. Results A total of 12 792 cases were registered, of whom 3023 (23.6%) were aged at least 75 years. About 20% patients had previous diabetes mellitus diagnosis. Patients aged at least 75 years had higher prevalence of comorbidities, higher proportion of heart failure at admission, a more extensive coronary artery disease and significant delay to reperfusion (P
Source: Coronary Artery Disease - Category: Cardiology Tags: Myocardial Infarction/Cardiogenic Shock Source Type: research

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Authors: Lancellotti P, De Pauw M, Claeys M Abstract Cardiovascular disease (CVD) and cancer represent the two main causes of death in industrialised countries. Both share common risk factors (diabetes, obesity, hypertension, diet, smoking, etc.). The associated timing of CVD and cancer onset is thus largely influenced by modifiable risk factors. Advances in cancer treatment have extended the lives of patients with cancer, but for some at the cost of adverse cardiovascular events. The rapidly growing number of patients surviving cancer, often in the setting of advanced age, new or pre-existing CV disease and risk f...
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
Authors: Acar RD, Acar Ş, Doğan C, Bayram Z, Karaduman A, Uysal S, Akbal ÖY, Hakgör A, Kaymaz C, Özdemir N Abstract INTRODUCTION: The aim of this study was to explore the relationship between the tricuspid annular plane systolic excursion/pulmonary arterial systolic pressure (TAPSE/PASP) ratio and model for end-stage liver disease (MELD) score in patients with advanced heart failure. METHODS: A total of 103 patients with advanced heart failure evaluated for candidacy for heart transplantation were included in this study. TAPSE was measured by M‑mode echocardiography and cardiac catheteri...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
CONCLUSION: In real-world patients at high risk of bleeding, implantation of the polymer-free metallic stent coated with Biolimus-A9 (Biofreedom®; Biosensors Europe, Morges, Switzerland) followed by 1 -month DAPT showed encouraging results without any stent thrombosis. PMID: 31965195 [PubMed - as supplied by publisher]
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
Background: Acute myocardial infarction (AMI) occurs as a result of irreversible damage to cardiac myocytes secondary to lack of blood supply. Cardiogenic shock complicating AMI has significant associated morbidity and mortality, and data on postdischarge outcomes are limited. Methods and Results: We derived the study cohort of patients with AMI and cardiogenic shock from the 2013 to 2014 Healthcare Cost and Utilization Project National Readmission Database. Incidence, predictors, and causes of 30-day readmissions were analyzed. From 43 212 index admissions for AMI with cardiogenic shock, 26 016 (60.2%) survived to discha...
Source: Circulation: Heart Failure - Category: Cardiology Authors: Tags: Heart Failure, Complications, Mortality/Survival, Quality and Outcomes, Acute Coronary Syndromes Original Articles Source Type: research
Authors: Aurigemma C, Burzotta F, Russo G, Previ L, Trani C Abstract The Completeness of Revascularization in patients with multivessel coronary artery disease (CAD) remains an unanswered question. Despite 20 years of investigation there are still major doubts in this topic, reaching as far as to the lack of a standardized definition. The employment of different definition and the multiplicity of confounding variables that in general favor patients who receive a complete revascularization (CR) are the reason of difficult comparisons between studies. The complexity of coronary anatomy diseases and the clinical featu...
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
Conclusion Patients with AMI and insignificant CAD have different clinical profile and outcome compared to those with significant disease.
Source: The Egyptian Heart Journal - Category: Cardiology Source Type: research
Conclusions In non-diabetic patients presented with STEMI, elevated admission glucose level was associated with adverse outcome and more severe multi-vessel coronary lesions. The cut-off value was >160mg/dl and was considered an independent factor in prediction of outcome of non-diabetics presented with SEMI. Measurement of admission blood glucose level enables identification of this high-risk group for aggressive secondary risk prevention.
Source: IJC Metabolic and Endocrine - Category: Endocrinology Source Type: research
ConclusionsThis parsimonious risk model for in-hospital mortality is a valid instrument for risk adjustment and  risk stratification in contemporary patients with acute myocardial infarction.
Source: Journal of the American College of Cardiology - Category: Cardiology Source Type: research
Authors: Juergens CP, Dabin B, French JK, Kritharides L, Hyun K, Kilian J, Chew DP, Brieger D Abstract OBJECTIVES: To investigate whether patients with English as their second language have similar acute coronary syndrome (ACS) outcomes to people whose first language is English. DESIGN: Retrospective, observational study, using admissions, treatment and follow-up data. PARTICIPANTS AND SETTING: A total of 6304 subjects from 41 sites enrolled in the investigator-initiated CONCORDANCE ACS registry. MAIN OUTCOME MEASURES: Baseline characteristics, treatments, and in-hospital and 6-month mortality. RESU...
Source: Medical Journal of Australia - Category: Journals (General) Tags: Med J Aust Source Type: research
Purpose of the study: To examine differences in the characteristics, treatment practices and in-hospital outcomes of patients with and without previously diagnosed diabetes hospitalized for non-ST segment elevation myocardial infarction. Key methods: The study cohort consisted of 3916 patients diagnosed with non-ST segment elevation myocardial infarction at all 11 central MA medical centres between 1999 and 2009, of whom 1475 (38%) had been previously diagnosed with diabetes. Main results: Diabetic patients were more likely to have received treatment with effective cardiac medications, and to have undergone coronary bypa...
Source: Diabetes and Vascular Disease Research - Category: Endocrinology Authors: Tags: Original Articles Source Type: research
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