B-ALL With t(5;14)(q31;q32); IGH-IL3 Rearrangement and Eosinophilia: A Comprehensive Analysis of a Peculiar IGH-Rearranged B-ALL

Conclusion: Based on shared epidemiological and biological features, B-cell acute lymphoblastic leukemia with t(5;14)(q31;q32) is a peculiar subset of IGH-rearranged B-cell acute lymphoblastic leukemia with an intermediate prognosis and particular clinical features related to eosinophilia.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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Four - year cumulative risk of any relapse lower for dasatinib in the context of intensive chemotherapy
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Oncology, Pathology, Pediatrics, Pharmacy, Journal, Source Type: news
TUESDAY, Jan. 21, 2020 -- Dasatinib is associated with improved survival for pediatric patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL), according to a study published online Jan. 16 in JAMA Oncology. Shuhong Shen,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
This research has the potential to aid in the development of new strategies for early detection of relapse in pediatric patients with ALL, and the development of treatments to counter clinical occurrence.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
Publication date: Available online 18 January 2020Source: BiologicalsAuthor(s): David GervaisAbstractErwinia chrysanthemi l-asparaginase (ErA) has been used for the treatment of acute lymphoblastic leukaemia (ALL) for decades, and its safety and efficacy have been well demonstrated. ErA drug substance and drug product contain a small proportion of acidic isoforms, with a known mechanism of formation, which have been shown to be minor conformational variants retaining enzymatic activity and function. Specifications for these acidic isoforms were set with an extremely limited data set, and with further manufacturing experien...
Source: Biologicals - Category: Biology Source Type: research
Condition:   Relapsed or Refractory Acute Lymphoblastic Leukemia Intervention:   Biological: single dose of CNCT19 Sponsor:   Juventas Cell Therapy Ltd. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The outcomes of allogeneic hematopoietic cell transplantation (HCT) in patients with non-remission acute lymphoblastic leukemia (ALL) remain poor. Although several studies have reported the outcomes, most of their cohort were small or consisted of heterogeneous populations [1 –11]. Heterogeneity of patient characteristics or criteria for non-remission status makes the interpretation of the results difficult. The detection of ALL cohorts with extremely poor prognosis after allogeneic HCT is particularly important from the point of optimal use of available medical resour ces, including its cost and donor's burden.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Authors: Sakai T, Sato K, Kikuchi T, Obata M, Konuma Y Abstract Mucormycosis has emerged as the third-most common fungal mycosis and is one of the most fatal molds. We herein report a case study of a 30-year-old woman who was a veterinarian, specializing in livestock, who developed disseminated mucormycosis during induction therapy for acute lymphoblastic leukemia. We successfully used a radical approach for treatment, including a surgical procedure and allogeneic transplantation, with continuous administration of antifungal agents. Reports of successful treatments are extremely rare, and our case has had the longe...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
The aim of the following case report is to provide a description of acute lymphoblastic leukemia (ALL) in a patient with Netherton syndrome (NS). A 15-year-old male with NS was referred with suspicion of acute leukemia. Severe anemia, leukocytosis, thrombocytopenia, and elevated CRP level were demonstrated in pre-hospital laboratory tests. Physical examination revealed generalized ichthyosiform erythroderma. ALL was diagnosed on the basis of bone marrow biopsy. The patient was initially classified as CNS3 status. No signals indicating fusion of BCR/ABL1, ETV6, and RUNX1 genes and MLL gene rearrangement were found in the cy...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Biomarkers are biological molecules found in body fluids or tissues, which can be considered as indications of a normal or abnormal process, or of a condition or disease. There are various types of biomarkers based on their application and molecular alterations. Treatment-sensitivity or drug resistance biomarkers include prognostic and predictive molecules with utmost importance in selecting appropriate treatment protocols and improving survival rates. Acute lymphoblastic leukemia (ALL) is the most prevalent hematological malignancy diagnosed in children with nearly 80% cure rate. Despite the favorable survival rates of ch...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Condition:   Relapsed or Refractory Acute Lymphoblastic Leukemia Intervention:   Biological: single dose of CNCT19 Sponsor:   Juventas Cell Therapy Ltd. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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