Severe myocarditis with slight lymphocytic infiltration after nivolumab treatment

Among the various reported adverse events associated with immune checkpoint inhibitors (ICIs), myocarditis is of particular concern in clinical practice as a relatively rare event but with an often fatal outcome [1]. However, the diagnosis of ICI-mediated myocarditis is challenging owing to its heterogeneous clinical presentation. Here, we report a case of histologically confirmed acute myocarditis showing only slight myocardial inflammation but severe left ventricular dysfunction after nivolumab treatment.

Source: Lung Cancer - December 8, 2019 Category: Cancer & Oncology Authors: Ryuya Edahiro, Takayuki Shiroyama, Sachiko Hijiki, Satoshi Nojima, Yuya Shirai, Shohei Koyama, Atsushi Kumanogoh Tags: Letter to the editor Source Type: research