Giving common antibiotic before radiation may help body fight cancer

(University of Pennsylvania School of Medicine) The antibiotic vancomycin alters the gut microbiome in a way that can help prime the immune system to more effectively attack tumor cells after radiation therapy.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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AbstractIntroductionWhile the current standard of care after maximal safe resection for glioblastoma (GBM) is concomitant radiation and chemotherapy, the ideal therapy for patients with poor performance status remains in question due to concerns about treatment tolerance. We sought to evaluate an alternative regimen, sequential radiation and chemotherapy, to assess its efficacy as a treatment option for poorly performing patients.MethodsWe performed a retrospective analysis using the 2015 National Cancer Database in which the survival of patients with a KPS  ≤ 70 who received sequential radiation and chemo...
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 18 January 2020Source: Seminars in Cancer BiologyAuthor(s): Zhenchang Wang, Kangkang Zhi, Zhongyang Ding, Yi Sun, Shuang Li, Manyuan Li, Kefeng Pu, Jun ZouAbstractCancer has thwarted as a major health problem affecting the global population. With an alarming increase in the patient population suffering from diverse varieties of cancers, the global demographic data predicts sharp escalation in the number of cancer patients. This can be expected to reach 420 million cases by 2025. Among the diverse types of cancers, the most frequently diagnosed cancers are the breast, colorectal, prostate ...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
ConclusionsThe review of the benchmark and rapid review QA submissions indicates that acceptable variations or unacceptable deviations for the ipsilateral lung and heart dose constraints were the most commonly observed cause of benchmark QA failure, and unacceptable deviations in target contouring, rather than normal structure contouring, were the most common cause of rapid review QA failure. These findings suggest that a rigorous QA process is necessary for high quality and homogeneity in radiation therapy in multi-institutional trials of breast cancer to ensure that the benefits of radiation therapy far outweigh the risks.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Interview with Trevor J. Royce, MD MS MPH, author of Analysis of Price Transparency via National Cancer Institute–Designated Cancer Centers’ Chargemasters for Prostate Cancer Radiation Therapy
Source: JAMA Specialty Journals Author Interviews - Category: General Medicine Authors: Source Type: podcasts
Over the past decade, several strides have been made to improve the management of breast cancer in developing countries; however, there are still obstacles present. In the area of radiation therapy, these hurdles include limited access to radiotherapy treatment and scarcity of oncology specialists. In an effort to reduce inequities in cancer care while improving patient outcomes, our research is focused on developing automated postmastectomy radiation therapy (PMRT) plans for breast cancer patients in these underserved communities that can be further improved upon through treatment planning system (TPS) specific optimization guidelines.
Source: Medical Dosimetry - Category: Radiology Authors: Tags: 2019 Student Writing Competition —1st Place Source Type: research
Stage I Non-Small Cell Lung Cancer (NSCLC) has a relatively good prognosis of 81% (stage IA) or 73% (stage IB) 5-year survival following curative treatments[1]. The most commonly used procedures follow current guidelines, which suggest operable patients should preferably be treated with the appropriate thoracoscopic resection technique with Video Assisted Thoracic Surgery (VATS), while Stereotactic Body Radiation Therapy (SBRT) is preferred in inoperable patients.[2 –4] These guidelines are based on current evidence, although there is disagreement whether there is equipoise for operable patients between SBRT and VATS resection.
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
AbstractPurpose of ReviewWith advances in radiation therapy (RT) techniques for rectal and anal cancers allowing for the modulation of critical normal tissues, there has been an increased emphasis on improving the quality of life (QOL) for cancer survivors. Herein, we review the literature to examine the impact of RT on QOL and patient-reported outcomes (PROs) to better inform providers about the challenges of survivorship.Recent FindingsLarge systematic reviews, recent studies, and long-term follow-up of pivotal clinical trials have shown that RT impacts QOL, particularly fecal continence and sexual function. Modern preop...
Source: Current Colorectal Cancer Reports - Category: Cancer & Oncology Source Type: research
AbstractPrevious studies have shown that breast cancer patients ’ beliefs regarding radiation therapy (RT) are influenced by a multitude of factors encompassing demographic, socioeconomic, cultural, and healthcare-related domains. The association between consultation with a multidisciplinary care team and breast cancer patients’ attitudes towards RT, howeve r, remains understudied. Using survey and medical record data from 185 women with invasive, non-metastatic breast cancer who received breast conserving surgery, we aimed to characterize the relationship between the number and type of oncological special...
Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: MRI surveillance with multiple rounds of SRS may serve a reasonable alternative to PCI or therapeutic WBRT in SCLC. PMID: 31927801 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
Conditions:   Thoracic Cancer;   Spine Cancer;   Thoracic Diseases;   Spine Disease;   Thoracic Neoplasms;   Spine Metastases Intervention:   Diagnostic Test: MRI with custom MRI spine coil Sponsor:   Memorial Sloan Kettering Cancer Center Recruiting
Source: - Category: Research Source Type: clinical trials
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