Effect of constraints on stress intensity factor for dissimilar metal plate with centre crack under uniform tension

Publication date: March 2020Source: Materials Today Communications, Volume 22Author(s): Muthu Kumaran M., Ramachandra Murthy A., Vishnuvardhan S.AbstractDissimilar metal joints (DMJs) are more common in the coolant systems of most of the engineering applications and are subjected to variety of loadings. To understand the constraint effect of the dissimilar metal welded joints (DMJs), fracture studies have been carried out on dissimilar metal plate (DMP) with center crack made up of ferritic steel (SA 508 Gr.3 Cl.1), austenitic steel (SA312 Type 304LN) and Inconel – 182 alloy (ENiCrFe-3). 2-D and 3-D finite element analysis (FEA) is carried out on the DMP with centre crack (length = 250 mm, width = 150 mm) for various crack lengths (15, 20, 30 and 50 mm) and various dissimilar metal welded joint widths (DMJWs) (5, 10, 20, 30, 40 and 50 mm) to evaluate stress intensity factor (SIF). SIF has been evaluated by employing domain integral method. It is observed from the studies that, (i) SIF increases with increase of crack length and DMJW, (ii) 3-D finite element analysis yields realistic SIF (iii) SIF of DMP reduces compared to homogenous plate, (iv) constraint effect is found to be significant if DMJW is less than the initial crack length, resulted in reduction of SIF (iv) constraint effect is found to be insignificant if DMJW is more than 20 mm and the ratio of crack length to DMJW is greater than 0.75. The stu...
Source: Materials Today Communications - Category: Materials Science Source Type: research

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Publication date: Available online 22 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Donna Goodenow, Faith Emmanuel, Chase Berman, Mark Sahyouni, Christine RichardsonAbstractBioflavonoids have a similar chemical structure to etoposide, the well-characterized topoisomerase II (Top2) poison, and evidence shows that they also induce DNA double-strand breaks (DSBs) and promote genome rearrangements. The purpose of this study was to determine the kinetics of bioflavonoid-induced DSB appearance and repair, and their dependence on Top2. Cells were exposed to bioflavonoids individu...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 21 January 2020Source: The American Journal of SurgeryAuthor(s): Kenneth H. Perrone, Su Yang, Hossein Mohamadipanah, Brett Wise, Anna Witt, Cassidi Goll, Carla PughAbstractBackgroundWe hypothesized that differences in motion data during a simulated laparoscopic ventral hernia repair (LVH) can be used to stratify top and lower tier performers and streamline video review.Materials and methodsSurgical residents (N = 94) performed a simulated partial LVH repair while wearing motion tracking sensors. We identified the top ten and lower ten performers based on a final product quality score ...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Today's research materials are representative of numerous initiatives aiming to produce taxonomies of the biochemistry of aging, to catalog the observed variations. Yet, with the exception of a very small number of unlucky souls bearing rare harmful mutations, we all age for the same underlying reasons. The same processes of metabolism produce the same forms of cell and tissue damage, leading to the same downstream dysfunctions and the same ultimately fatal age-related conditions. Yes, there is some variation in outcome. For all that aging is a universally similar process of multiple interacting forms of damage, some porti...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Publication date: May 2020Source: Materials Science and Engineering: C, Volume 110Author(s): Chengcheng Yin, Xiaoshi Jia, Qin Zhao, Zifan Zhao, Jinyang Wang, Yufeng Zhang, Zhi Li, Hongchen Sun, Zubing LiAbstractBoron-containing mesoporous bioactive glass (B-MBG) scaffolds could be capable of promoting osteogenesis by activating Wnt/β-catenin signaling pathway during the process of bone defect repair. Despite this, more involving molecular controls are still largely unclear. In the present study, we identified that the downstream of Wnt/β-catenin signaling pathway named transcription factor 7-like 2 (TCF7L2) serve...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: 21 January 2020Source: Cell Reports, Volume 30, Issue 3Author(s): Orit Harari-Steinberg, Dorit Omer, Yehudit Gnatek, Oren Pleniceanu, Sanja Goldberg, Osnat Cohen-Zontag, Sara Pri-Chen, Itamar Kanter, Nissim Ben Haim, Eli Becker, Roi Ankawa, Yaron Fuchs, Tomer Kalisky, Zohar Dotan, Benjamin DekelSummaryEnd-stage renal disease is a worldwide epidemic requiring renal replacement therapy. Harvesting tissue from failing kidneys and autotransplantation of tissue progenitors could theoretically delay the need for dialysis. Here we use healthy and end-stage human adult kidneys to robustly expand proliferative kid...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 21 January 2020Source: Cell Reports, Volume 30, Issue 3Author(s): Jennifer Ann Black, Kathryn Crouch, Leandro Lemgruber, Craig Lapsley, Nicholas Dickens, Luiz R.O. Tosi, Jeremy C. Mottram, Richard McCullochSummaryTrypanosoma brucei evades mammalian immunity by using recombination to switch its surface-expressed variant surface glycoprotein (VSG), while ensuring that only one of many subtelomeric multigene VSG expression sites are transcribed at a time. DNA repair activities have been implicated in the catalysis of VSG switching by recombination, not transcriptional control. How VSG switching is signaled t...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 21 January 2020Source: Cell Reports, Volume 30, Issue 3Author(s): Carmit Hillel-Karniel, Chava Rosen, Irit Milman-Krentsis, Ran Orgad, Esther Bachar-Lustig, Elias Shezen, Yair ReisnerSummaryInduction of lung regeneration by transplantation of lung progenitor cells is a critical preclinical challenge. Recently, we demonstrated that robust lung regeneration can be achieved if the endogenous stem cell niches in the recipient’s lung are vacated by sub-lethal pre-conditioning. However, overcoming MHC barriers is an additional requirement for clinical application of this attractive approach. We demonstrat...
Source: Cell Reports - Category: Cytology Source Type: research
CONCLUSIONS: ANXA7 knockdown increased the radiosensitivity of NPC by enhancing apoptosis, modulating the cell cycle distribution into more radiosensitive phases, promoting DNA damage, and inhibiting repair. We showed that decreased ANXA7 levels enhanced radiosensitivity and provided insights into the therapeutic targets for NPC radiotherapy. PMID: 31958076 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
Increased rates of locoregional recurrence are observed in patients with basal-like breast cancer (BC) despite the use of radiation therapy (RT); therefore, approaches that result in radiosensitization of basal-like BC are critically needed. Using patients’ tumor gene expression data from 4 independent data sets, we correlated gene expression with recurrence to find genes significantly correlated with early recurrence after RT. The highest-ranked gene, TTK, was most highly expressed in basal-like BC across multiple data sets. Inhibition of TTK by both genetic and pharmacologic methods enhanced radiosensitivity in mul...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
With a focus on renal function, the goal of this multicentre study was to assess peri-operative complications and late mortality of open surgical repair (OSR) of juxtarenal abdominal aortic aneurysms (JRAAA).
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
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