A biomimetic nano-hydroxyapatite/chitosan/poly(methyl vinyl ether-alt-maleic anhydride) composite with excellent biocompatibility

Publication date: 15 February 2020Source: Materials Letters, Volume 261Author(s): Pengfei Ren, Faming Wang, Tiantian Zhan, Wanjun Hu, Naizhen Zhou, Tianzhu Zhang, Jinhai YeAbstractNano-hydroxyapatite/chitosan/poly(methyl vinyl ether-alt-maleic anhydride) (NHA/CS/P(MVE-alt-MA)) composite was formed through electrostatic interaction. The results of characterization indicated that the nano-hydroxyapatite (NHA) in the composites was uniformly distributed in the polymer matrices (chitosan/poly(methyl vinyl ether-alt-maleic anhydride) (CS/P(MVE-alt-MA)). With the increase of NHA content, the porosity and strength of the composites increase first and then decrease. The mechanical properties of composite were better than those of the three kinds of single component, the maximum compressive strength of composite was up to 8.48 MPa. Moreover, this composite showed excellent biocompatibility through SD rat bone marrow mesenchymal stem cells (SDBMSCs) culture. Therefore, this composite which combined the advantages of various materials exhibited good mechanical properties and biocompatibility, it was expected to be applied in bone tissue repair.Graphical abstract
Source: Materials Letters - Category: Materials Science Source Type: research

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Source: Materials Today - Category: Materials Science Source Type: research
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Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
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