Commentary: Staphylococcus aureus, the master of disaster in intracardiac prosthetic infective endocarditis on a new battlefield with antiplatelet agents

Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research

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Abstract Infective endocarditis is a life-threatening and enigmatic disease with a mortality of 30% and a pathophysiology that is poorly understood. However, at its core, an endocarditis lesion is mainly a fibrin and platelet blood clot infested with bacteria, clinging at the cardiac valves. Infective endocarditis therefore serves as a paradigm of immunothrombosis gone wrong. Immunothrombosis refers to the entanglement of the coagulation system with innate immunity and the role of coagulation in the isolation and clearance of invading pathogens. However, in the case of infective endocarditis, instead of containing...
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: J Thromb Haemost Source Type: research
Publication date: January 2020Source: Archives of Cardiovascular Diseases Supplements, Volume 12, Issue 1Author(s): I. Chamtouri, A. Farah, R. Khalifa, W. Jomaa, K. Ben Hamda, F. MaatoukIntroductionDespite the progress in diagnostic modalities and therapeutic strategies, Infective endocarditis remains a lethal disease especially in children.AimWe aimed to update current characteristics of infective endocarditis in children and to identify complications.Patients and methodsWe carried out in our department a retrospective study including 40 children diagnosed with infective endocarditis (IE) between 1983 and 2017.ResultsFort...
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
Publication date: January 2020Source: Archives of Cardiovascular Diseases Supplements, Volume 12, Issue 1Author(s): M. Selegny, S. Dirani, S. Cohen, F. Godart, I. Durand, P. Maragnes, B. Urbina-Hiel, E. Bourges-Petit, A. MathironBackgroundCongenital heart disease (CHD) represents a predisposing condition for the development of infective endocarditis (IE). In recent years, the reduction in the incidence of rheumatic heart disease, advances in cardiac surgery and the increased use of long-term central venous catheters (CVC) in subjects without CHD have changed significantly the epidemiology of the disease. We sought to evalu...
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
ConclusionsA predictive model of in-hospital mortality in left-sided IE based on the prognostic variables proposed by the European Society of Cardiology IE guidelines has high discriminatory ability.ResumenIntroducción y objetivosLa endocarditis infecciosa (EI) es una enfermedad compleja con elevada mortalidad. La evaluación pronóstica es esencial en el tratamiento de la enfermedad; sin embargo, las guías internacionales no aportan una evaluación objetiva del riesgo individual. Se desarrolló un modelo predictivo de mortalidad hospitalaria en EI izquierda combinando las variables pr...
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
In this issue of the Journal, Ditkowski and colleagues,1 through an elaborate series of in  vitro experiments, present compelling evidence for the prominent role of platelets and fibrinogen in the development of Staphylococcus aureus infective endocarditis (IE) of biologic heart valve conduits.1 Specifically, they focus on the complex interaction of Staphylococcus clumping factor A (ClfA ), fibrinogen, platelet αIIbβ3 receptors, and platelet adenosine diphosphate receptors as modulators of bacterial adhesion on various graft tissues.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Commentary Source Type: research
ConclusionIn subjects with complicated and prolonged MRSA bacteremia requiring supplemental ceftaroline, clinical outcomes did not differ among patients prescribed vancomycin or daptomycin alone following bacteremia resolution versus patients who continued combination therapy.
Source: Infectious Diseases and Therapy - Category: Infectious Diseases Source Type: research
Although recent advances in pulmonary valve replacement have enabled excellent hemodynamics, infective endocarditis remains a serious complication, particularly for implanted bovine jugular vein (BJV) conduits.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Basic Science Source Type: research
Although recent advances in pulmonary valve replacement have enabled excellent hemodynamics, infective endocarditis remains a serious complication, particularly for implanted bovine jugular vein (BJV) conduits.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
Abstract Osteoarticular infections (OAIs) in the setting of infective endocarditis (IE) are uncommon. Although morbidity and mortality have been widely studied, details of the characteristics of patients with concurrent IE and OAI are limited. Therefore, the purpose of this study was to determine the (1) incidence, (2) mortality, (3) clinical features, and (4) microbiological profiles of OAIs in the setting of IE. A retrospective review was conducted of 1280 IE cases at a large academic institution between 2009 and 2015. Patients were categorized according to the following OAI types: spondylodiskitis, large joint ...
Source: Orthopedics - Category: Orthopaedics Authors: Tags: Orthopedics Source Type: research
We present a case of Staphylococcus aureus Eustachian valve endocarditis in an individual without traditional risk factors. PMID: 31656424 [PubMed]
Source: Baylor University Medical Center Proceedings - Category: Universities & Medical Training Authors: Tags: Proc (Bayl Univ Med Cent) Source Type: research
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