Quadrivalent VesiculoVax vaccine protects nonhuman primates from viral-induced hemorrhagic fever and death
Recent occurrences of filoviruses and the arenavirus Lassa virus (LASV) in overlapping endemic areas of Africa highlight the need for a prophylactic vaccine that would confer protection against all of these viruses that cause lethal hemorrhagic fever (HF). We developed a quadrivalent formulation of VesiculoVax that contains recombinant vesicular stomatitis virus (rVSV) vectors expressing filovirus glycoproteins and that also contains a rVSV vector expressing the glycoprotein of a lineage IV strain of LASV. Cynomolgus macaques were vaccinated twice with the quadrivalent formulation, followed by challenge 28 days after the boost vaccination with each of the 3 corresponding filoviruses (Ebola, Sudan, Marburg) or a heterologous contemporary lineage II strain of LASV. Serum IgG and neutralizing antibody responses specific for all 4 glycoproteins were detected in all vaccinated animals. A modest and balanced cell-mediated immune response specific for the glycoproteins was also detected in most of the vaccinated macaques. Regardless of the level of total glycoprotein-specific immune response detected after vaccination, all immunized animals were protected from disease and death following lethal challenges. These findings indicate that vaccination with attenuated rVSV vectors each expressing a single HF virus glycoprotein may provide protection against those filoviruses and LASV most commonly responsible for outbreaks of severe HF in Africa.
Travel links to city shut down in bid to curb worst viral outbreak since Sars in 2003
An outbreak of new coronavirus in China has sickened more than 500 people and killed at least a dozen, while spreading to countries around the world.
Snakes -- the Chinese krait and the Chinese cobra -- may be the original source of the newly discovered coronavirus that has triggered an outbreak of a deadly infectious respiratory illness in China this winter.
At least 17 people have died from the mystery illness. The sudden uptick in deaths prompted the authorities to ban most forms of travel from Wuhan, China, the epicenter of the outbreak, ahead of the biggest travel day of the year.
China is putting on lockdown a city of 11 million people considered the epicenter of a new coronavirus outbreak that has killed 17 and infected nearly 600, as health authorities around the world scramble to prevent a global pandemic.
China's transport ministry on Thursday suspended all shuttle buses and ferries going to the central city of Wuhan due to a coronavirus outbreak that has killed 17 and infected nearly 600.
Britain's business minister said on Thursday that the outbreak of a new coronavirus in China was a huge concern for the world.
Shortly before authorities closed off the Chinese city at the epicenter of an outbreak of a new virus, the World Health Organization sent a team to check conditions on the ground in Wuhan, a city of more than 11 million people
As China releases details about the 17 people who have died in the outbreak, a well-known SARS expert raises an alarm about the virus ’s spread, saying he feels “powerless.”
An outbreak of a new coronavirus that began in the central Chinese city of Wuhan has killed 17 and infected nearly 600 people globally.