Silicon-incorporated nanohydroxyapatite-reinforced poly(ε-caprolactone) film to enhance osteogenesis for bone tissue engineering applications

Publication date: Available online 9 December 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Ting Lei, Wanqi Zhang, Hu Qian, Poon Nian Lim, Eng San Thian, Pengfei Lei, Yihe Hu, Zuyong WangAbstractBiomaterials composed of polymers and bioceramics have great prospects to repair large and complicated bone defects. Here, we developed a composite film consisting of poly(∑-caprolactone) (PCL) and silicon-substituted hydroxyapatite (Si-HA) nanoparticles to enhance the osteogenic effects of the scaffold for bone tissue engineering applications. The results showed that the Si-HA nanoparticles obtained an even distribution in the PCL matrix, resulting in a homogeneous composite film. Compared to HA-incorporated PCL film, the addition of silicon did not cause hydrophilic alterations to the film surface. With the seeding of mouse calvarial preosteoblasts (MC3T3-E1), the cells exhibited the good behaviors of adhesion and growth on the PCL/Si-HA film. Compared to the PCL/HA films, incorporation of Si-HA nanoparticles in PCL/Si-HA films showed the increased production of alkaline phosphatase and calcium content by MC3T3-E1 cells. These results suggested the suitability of the PCL/Si-HA composite film to elicit cellular growth and functional differentiation with the potential for bone tissue engineering applications.Graphical abstract
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research

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Publication date: Available online 26 January 2020Source: Carbohydrate PolymersAuthor(s): Resmi Rajalekshmi, Parvathy Jayasree, John Annie, Joseph RoyAbstractInjectable in situ gelling hydrogels are viable treatment options for meniscal injuries occurring in athletes. The present study aims to develop an injectable hydrogel via borax complexation of oxidized alginate, followed by a self-crosslinking reaction with gelatin through a Schiff’s base reaction. Gelation kinetics and degree of crosslinking could be controlled by changing the concentration of components and the formation of Schiff's base formation was confir...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news
Condition:   Total Anomalous Pulmonary Venous Connection Interventions:   Drug: Anticoagulant Solutions;   Other: No anticoagulant solutions;   Drug: Anticoagulant management Sponsor:   Guangdong Provincial People's Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Source: Food and Drug Adminstration (FDA): CDRHNew - Category: Medical Devices Authors: Source Type: news
ACS Applied Materials&InterfacesDOI: 10.1021/acsami.9b20185
Source: ACS Applied Materials and Interfaces - Category: Materials Science Authors: Source Type: research
Publication date: 25 March 2020Source: Journal of Industrial and Engineering Chemistry, Volume 83Author(s): Vaikundamoorthy Ramalingam, Inho HwangAbstractIn the present study, we investigated the effect of monodispersed zinc oxide (ZnO) nanoparticles on the proliferation, myogenic differentiation and regulation of associated myogenic marker genes. The as-prepared ZnO nanoparticles had the hexagonal wurtzite structure with maximum absorption at 355 nm and the band gap energy was found to be 3.21 eV. The electron microscopy analysis showed that the ZnO nanoparticles are spherical in shape with an average size range...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
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Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Publication date: Available online 25 December 2019Source: The Journal of Molecular DiagnosticsAuthor(s): Maribel González-Acosta, Inga Hinrichsen, Anna Fernández, Conxi Lázaro, Marta Pineda, Guido Plotz, Gabriel CapelláA significant proportion of DNA-mismatch repair (MMR) variants are classified as of unknown significance, precluding diagnosis. The in vitro MMR assay is used to assess their MMR capability, likely the most important function of an MMR protein. However, the robustness of the assay, crucial for its use in the clinical setting, has been rarely evaluated. The aim of the present...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
International Dental Journal, Volume 70, Issue 1, Page 7-8, February 2020.
Source: International Dental Journal - Category: Dentistry Authors: Tags: Policy Statement Source Type: research
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Source: Current Reviews in Musculoskeletal Medicine - Category: Orthopaedics Source Type: research
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