What is the Criteria for Diagnosing Beçhet’s disease?

Discussion Beçhet’s disease (BD) is a multisystem vasculitis named for the Turkish dermatologist, Hulusi Beçhet. It has a prevalance in one study of 5.2-7.1 per 100,000 adults. It is more common in males than females but it depends on the cohort studied and there is variation among different ancestral groups. Venous vasculitis usually causes thrombotic events whereas arterial vasculitis causes aneurysms and thrombosis. Involvement of the central nervous system vasculature can be a major problem. Central venous thrombosis can cause isolated intracranial hypertension but also aphasia, hemiparesis and seizures. Pulmonary aneurysms are the leading cause of death in adults. Unlike many other autoimmune diseases BD usually does not affect the kidney. Gastrointestinal disease may be seen such as diarrhea and abdominal pain. Nonerosive arthritis particularly of the knees is also seen. The actual cause is unknown but it is associated with several genetic factors including HLA-B5. As this is a syndrome there is no specific testing but other tests are done to exclude other diagnoses. ESR and C-reactive protein may be slightly elevated. Anti-nuclear antibodies, antineutrophil cytoplasmic antibodies and rheumatoid factor are usually negative. Treatment depends on the organ involvement including topical treatment for ulcers, and antiinflammatory medications for more serious disease. Azothioprine is often used for uveitis and cholchicine for nodules of the skin. CNS ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news

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We describe the most highly recommended generic and disease-specific PRO tools in SCD and discuss the challenges of incorporating them in clinical practice. EXPERT OPINION: PRO measures are essential to incorporate into SCD clinical trials either as primary or secondary outcomes. The use of PRO measures in SCD facilitates a patient-centered approach, which is likely to lead to improved outcomes. Significant challenges remain in adapting PRO tools to routine clinical use and in developing countries. PMID: 33034214 [PubMed - as supplied by publisher]
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Authors: Bergland OU, Søraas CL, Larstorp ACK, Halvorsen LV, Hjørnholm U, Hoffman P, Høieggen A, Fadl Elmula FEM Abstract PURPOSE: The blood pressure (BP) lowering effect of renal sympathetic denervation (RDN) in treatment-resistant hypertension shows variation amongst the existing randomised studies. The long-term efficacy and safety of RDN require further investigation. For the first time, we report BP changes and safety up to 7 years after RDN, compared to drug adjustment in the randomised Oslo RDN study. MATERIALS AND METHODS: Patients with treatment-resistant hypertension, defined...
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
Authors: Zhang W, Xu JZ, Lu XH, Li H, Wang D, Wang JG Abstract PURPOSE: We hypothesise that dietary sodium intake interacts with serum uric acid to influence blood pressure (BP) in children and adolescents. In the present study, we investigated ambulatory BP in relation to hyperuricaemia, dietary sodium intake and their interaction in children and adolescents with hypertension. MATERIALS AND METHODS:  A total of 616 study participants were 10-24 years old and had primary hypertension diagnosed after admission in a specialised inpatient ward. Ambulatory BP monitoring was performed during hospitalisat...
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
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Currently in fellowship doing bread/butter procedures (MBB, epidurals, PNB, few SCS/PNS trials, etc.) and just interviewed at a private practice spot where they do a lot of procedures that I will have not done any training in prior to graduating (e.g. IT pump, SI fusion, Vertiflex, Kypho, MILD, Discectomy, lots of SCS/PNS trials etc) and significant amount of "OR pain procedures" at a very busy practice seeing 30-40 pts/day - how many of you are commonly performing these procedures and are... private practice concern
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
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