Executive task-based brain function in children with type 1 diabetes: An observational study

by Lara C. Foland-Ross, Bruce Buckingam, Nelly Mauras, Ana Maria Arbelaez, William V. Tamborlane, Eva Tsalikian, Allison Cato, Gabby Tong, Kimberly Englert, Paul K. Mazaika, Allan L. Reiss, for the Diabetes Research in Children Network (DirecNet) BackgroundOptimal glycemic control is particularly difficult to achieve in children and adolescents with type 1 diabetes (T1D), yet the influence of dysglycemia on the developing brain remains poorly understood. Methods and findingsUsing a large multi-site study framework, we investigated activation patterns using functional magnetic resonance imaging (fMRI) in 93 children with T1D (mean age 11.5 ± 1.8 years; 45.2% female) and 57 non-diabetic (control) children (mean age 11.8 ± 1.5 years; 50.9% female) as they performed an executive function paradigm, the go/no-go task. Children underwent scanning and cognitive and clinical assessment at 1 of 5 different sites. Group differences in activat ion occurring during the contrast of “no-go> go ” were examined while controlling for age, sex, and scan site. Results indicated that, despite equivalent task performance between the 2 groups, children with T1D exhibited increased activation in executive control regions (e.g., dorsolateral prefrontal and supramarginal gyri;p = 0.010) and reduced suppression of activation in the posterior node of the default mode network (DMN;p = 0.006). Secondary analyses indicated associations between activation patterns and behavior a...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research

Related Links:

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionsThis case report demonstrates an unusual etiology of back and leg pain in a young man and elucidates the palliative effects of radiation therapy for epithelioid hemangioma involving the lumbar spine.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
M. Piasecki1*, A. Ireland2, J. Piasecki3, H. Degens2,4, D. W. Stashuk5, A. Swiecicka6, M. K. Rutter6,7, D. A. Jones2 and J. S. McPhee8,9* 1Clinical, Metabolic and Molecular Physiology, MRC-ARUK Centre for Musculoskeletal Ageing Research, National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom 2School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom 3Musculoskeletal Physiology Research Group, Sport, Health and Performance Enhancement Research Centre, School of Science and Technology, Nottingham Tre...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusion Taken together, evidence from animal and human studies demonstrates that the brain detects levels of circulating nutrients and hormones and consequently organizes an outward response that contributes to the regulation of whole-body glucose homeostasis. However, there are major knowledge gaps about the exact nature of this response and its relative importance compared to peripheral processes. As we have seen, animal studies have provided an anatomical map of CNS glucose regulation and have identified important neurons and neural circuits involved. Additionally, the CNS sensing of key nutrients and hormones has b...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
This study defines a new clinically relevant concept of T-cell senescence-mediated inflammatory responses in the pathophysiology of abnormal glucose homeostasis. We also found that T-cell senescence is associated with systemic inflammation and alters hepatic glucose homeostasis. The rational modulation of T-cell senescence would be a promising avenue for the treatment or prevention of diabetes. Intron Retention via Alternative Splicing as a Signature of Aging https://www.fightaging.org/archives/2019/03/intron-retention-via-alternative-splicing-as-a-signature-of-aging/ In recent years researchers have inv...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging. Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Molecular imaging of diabetes and diabetic complications: beyond pancreatic β-cell targeting. Adv Drug Deliv Rev. 2018 Dec 05;: Authors: Yang J, Zhang LJ, Wang F, Hong T, Liu Z Abstract Diabetes is a chronic non-communicable disease affecting over 400 million people worldwide. Diabetic patients are at a high risk of various complications, such as cardiovascular, renal, and other diseases. The pathogenesis of diabetes (both type 1 and type 2 diabetes) is associated with a functional impairment of pancreatic β-cells. Consequently, most efforts to manage and prevent diabetes have focused on pre...
Source: Advanced Drug Delivery Reviews - Category: Drugs & Pharmacology Authors: Tags: Adv Drug Deliv Rev Source Type: research
We are living at the dawn of the nanomedicine age. I believe that nanoparticles and nanodevices will soon operate as precise drug delivery systems, cancer treatment tools or tiny surgeons. Let me introduce you the brave, new world of nanotechnology in healthcare. Nanorobots having nanobreakfast with your red and white blood cells When I was a kid, one of my favorite TV series was a French animation, Il était un fois… la vie (1986). I found it fascinating how the creators imagined the human body as a construction where tiny cars floated through the human veins, grab-cranes worked on teeth and bacteria as tiny ...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Nanotechnology in Medicine cancer treatment drug delivery system future GC1 Healthcare Innovation nanodevices nanoparticles robotics wearables Source Type: blogs
ObjectiveDifferences in cognition and brain structure have been found in youth with type 1 diabetes compared with controls, even after relatively short disease duration. To determine whether severity of clinical presentation contributes to these differences, we obtained structural magnetic resonance imaging (MRI) scans in youth ages 7–17 who were either newly diagnosed with type 1 diabetes (
Source: Pediatric Diabetes - Category: Endocrinology Authors: Tags: Original Article Source Type: research
PurposeTo evaluate if diffusion tensor imaging MR neurography (DTI‐MRN) can detect lesions of peripheral nerves in patients with type 1 diabetes. Materials and MethodsEleven type 1 diabetic patients with polyneuropathy (DPN), 10 type 1 diabetic patients without polyneuropathy (nDPN), and 10 healthy controls (HC) were investigated with a 3T MRI scanner. Clinical examinations, nerve‐conduction studies, and vibratory‐perception thresholds determined the presence of DPN. DTI‐MRN (voxel size: 1.4 × 1.4 × 3 mm3; b‐values: 0, 800 s/mm2) covered proximal (sciatic nerve) and distal regions of the lower ...
Source: Journal of Magnetic Resonance Imaging - Category: Radiology Authors: Tags: Original Research Source Type: research
More News: Brain | Children | Diabetes | Diabetes Type 1 | Endocrinology | Internal Medicine | MRI Scan | Neurology | PET Scan | Study