Closed incision negative pressure therapy: Results of recent trials and recommendations for clinical practice

ConclusionciNPWT in open abdominal surgery has demonstrated promising results for reducing SSI rate in some trials however, patient selection remains unclear. Recent randomized controlled trials have failed to demonstrate benefit overall with use of ciNPWT in open abdominal surgery. Further multicentre prospective trials are needed for cost-benefit analysis and appropriate patient-selection.
Source: The Surgeon - Category: Surgery Source Type: research

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RESUMO Objetivo: Caracterizar os pacientes com doen ça crítica crônica e identificar os preditores relacionados à evolução para doença crítica crônica. Métodos: Coleta prospectiva de dados por 1 ano realizada na unidade de terapia intensiva de um hospital geral localizado na Região Sul do país. Construíram-se três modelos de regressão logística para identificar os fatores associados com doença crítica crônica. Resultados: Dentre os 574 pacientes admitidos à unidade de terapia intensiva dur...
Source: Revista Brasileira de Terapia Intensiva - Category: Intensive Care Source Type: research
Authors: Horch RE, Ludolph I, Müller-Seubert W, Zetzmann K, Hauck T, Arkudas A, Geierlehner A Abstract INTRODUCTION: The treatment of chronic wounds constitutes a massive financial burden to society and our health care system. Therefore, efficient wound care is of great importance to all kind of medical fields. The implementation and modification of negative pressure wound therapy can be seen as a major improvement on wound healing. Many different NPWT applications evolved trying to address various wound etiologies.Areas covered: This review aims to give an overview of various NPWT applications, show its effec...
Source: Expert Review of Medical Devices - Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research
Conclusions Circumferential negative intermittent pressure of 125 mm Hg applied to the midarm of healthy volunteers for 9 hours does not adversely affect digital SpO2.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Research Source Type: research
Conclusion: In this study, the use of nasal protective film (transparent film) prolonged the duration of pressure ulcer formation on the nasal bridge in patients who underwent noninvasive mechanical ventilation.
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
DiscussionExpected results will inform prescription and reimbursement practice of phase-change material-based prosthesis liners and will help improve and economize prosthetic fitting for people with limb loss. The design and duration of the protocol, including randomization, blinding, and within-subject comparison, will generate scientific evidence of a comparably high level. Inclusion of a comparably large sample and different climates, e.g. across all four seasons, will make findings applicable to a large number of prosthesis users.Trial,NCT03428815. Registered on 12 February 2018.
Source: Trials - Category: Research Source Type: clinical trials
ConclusionsThis systematic review of observational studies provided supportive evidence that NWPT is an efficient and safe adjunct treatment in the management of DFUs.
Source: Endocrine - Category: Endocrinology Source Type: research
Conclusion: The protective function of cZNF609 silence in H2O2-injured HaCaT cells was revealed in vitro. Silence of cZNF609 exhibited its impact possibly through regulating miR-145, and JNK and p38MAPK pathways. PMID: 31905030 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Although the wound-healing period for purse-string closure (PSC) after stoma reversal is longer than that required for the primary closure method, the rate of wound infection is reduced. The application of neg...
Source: Trials - Category: General Medicine Authors: Tags: Study protocol Source Type: research
This article is filled with practical information for the wound care practitioner, but does include some basic information including anatomy of aging skin and current theories of aging. When writing this review I searched around for a good schematic diagram that demonstrated aging skin but had a hard time finding one.  So I got out my art supplies and did my own diagram based upon available information on anatomy and physiology of aging.  Here it is below. This review also presents the latest information on skin failure and how the concept of SCALE, or Skin Changes at Life’s End, intersects with current un...
Source: Jeffrey M. Levine MD | Geriatric Specialist | Wound Care | Pressure Ulcers - Category: Geriatrics Authors: Tags: An Aging World Featured Medical Articles Geriatric Medicine Pressure Injuries & Wound Care Publications aging skin bedsores changes with age decubiti decubitus ulcer geriatrics gerontology histology of aging skin Jeff Levine MD Source Type: blogs
AbstractBackgroundNegative pressure wound therapy (NPWT) is a promising advance in the management of closed surgical incisions. NPWT application induces several effects locally within the wound including reduced lateral tension and improving lymphatic drainage. As a result, NPWT may improve wound healing and reduce surgical site complications. We aim to evaluate the efficacy of prophylactic application of NPWT in preventing surgical site complications for closed incisions in breast surgery.MethodsThis systematic review was reported according to PRISMA guidelines. The protocol was published in PROSPERO (CRD42018114625). Med...
Source: World Journal of Surgery - Category: Surgery Source Type: research
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