COMMENCE trial (Comparing hypOtherMic teMperaturEs duriNg hemiarCh surgEry): a randomized controlled trial of mild vs moderate hypothermia on patient outcomes in aortic hemiarch surgery with anterograde cerebral perfusion

This study proposes a multi-center RCT in order to compare outcomes of warmer hypothermic strategies during aortic hemiarch surgery on a composite endpoint of neurologic and acute kidney injury (AKI).Methods/designThis is a prospective multi-center, single-blind two-arm RCT comparing mild (32  °C) versus moderate (26 °C) hypothermic cardiac arrest in patients (n = 282) undergoing hemiarch surgery with antegrade cerebral perfusion (ACP). The primary endpoint is a composite of neurological injury (incidence of transient ischemic attack and/or stroke) and Kidney Disease Improving Global Outcomes (KDIGO) stage 1 or higher AKI. Secondary outcomes include de ath, cardiopulmonary bypass time, bleeding, transfusion rates, prolonged mechanical ventilation, myocardial infarction, length of stay, and quality of life measures.Patients will undergo 1:1 block randomization to each treatment arm on day of surgery. Sequence of operation will be at the surgeon ’s discretion with mandatory guidelines for temperature and ACP administration. Perioperative management will occur as per enrolling center standard of care. Neurocognitive function will be assessed for neurological injury using validated neurological screening tests: NIHSS, MOCA, BI, and MRS thro ughout patient follow-up. Diagnosis and classification of AKI will be based on rising creatinine values as per the KDIGO criteria. Study duration for each patient will be 60 ± 14&t...
Source: Trials - Category: Research Source Type: clinical trials

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Getting the right care in a timely manner is important in medical emergencies. In the event that you or a loved one suffers a stroke, time is especially critical. “In the event of a stroke, a delay of only 15 minutes in treatment greatly decreases your chances not only of making a full recovery, but also being able to walk or live independently, and in many cases, of survival,” says Christopher Zammit, MD, a critical care specialist and emergency physic ian with TriHealth, which offers a network…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Authors: Zhang Y, Liu Y, Zhu J, Zhai S, Jin R, Wen C Abstract The Traditional Chinese Medicine (TCM) formula is the main treatment method of TCM. A formula often contains multiple herbs where core herbs play a critical therapeutic effect for treating diseases. It is of great significance to find out the core herbs in formulae for providing evidences and references for the clinical application of Chinese herbs and formulae. In this paper, we propose a core herb discovery model CHDSC based on semantic analysis and community detection to discover the core herbs for treating a certain disease from large-scale literatur...
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Tags: Comput Math Methods Med Source Type: research
Publication date: October 2020Source: Journal of the Formosan Medical Association, Volume 119, Issue 10Author(s): Po-Ting Lin, Wei Teng, Wen-Juei Jeng, Chun-Yen Lin
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Publication date: Available online 22 September 2020Source: Journal of Critical CareAuthor(s): Ramona Düggelin, Marco Maggiorini, Stefanie Voigtsberger, Urs Schwarz, Matthias P. Hilty
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
Today, approximately 20% of the U.S. population — about 60 million people — live in rural areas, which make up 97% of the land area in the United States. People living in rural America have less access to health care and are more likely than residents of urban areas to die from chronic conditions such as heart disease, cancer, stroke, and chronic lower respiratory disease. Moreover, long-standing systemic health and social inequities have put many rural residents at increased risk of getting COVID-19. The rural/urban inequities in health and health care warrant more rigorous and innovative scientific research t...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
CONCLUSIONS: In patients with a high prevalence of acute coronary syndrome, Orsiro stents were not inferior to BioMatrix stents. Both showed excellent clinical outcomes. PMID: 32958459 [PubMed - as supplied by publisher]
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
Conditions:   Trauma Injury;   Haemorrhagic Shock;   Bleeding;   Emergencies;   Blood Transfusion;   Massive Hemorrhage;   Massive Transfusion;   Adult;   Bleeding Hemorrhage;   Hemorrhage / Mortality;   Cohort Study;   Female;   Male;   Hospital Mortality;   Humans;   Models, Theore tical;   Prognosis;   Wounds and Injuries / Mortality Intervention:   Other: Comparison of score performances (Overall performance, discrimination and calibration) Sponsor: &n...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Stroke Interventions:   Device: Virtual Reality;   Device: Action Observation Therapy;   Device: Landscape video;   Other: Standard treatment Sponsor:   Fondazione Don Carlo Gnocchi Onlus Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   SARS-CoV-2;   Post-stroke Depression;   Anxiety and Fear Intervention:   Sponsor:   Fatih Sultan Mehmet Training and Research Hospital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Stroke Intervention:   Behavioral: Narrative and Skills-building Intervention Sponsor:   Chinese University of Hong Kong Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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