Dealing with the unknown. Functional neurological disorder (FND) and the conversion of cultural meaning
Publication date: Available online 9 December 2019Source: Social Science &MedicineAuthor(s): Maddalena Canna, Rebecca SeligmanAbstractFunctional Neurological Disorder (FND), otherwise known as Conversion Disorder, is characterized by abnormal sensory or motor symptoms that are determined to be “incompatible” with neurological disease. FND patients are a challenge for contemporary medicine. They experience high levels of distress, disability, and social isolation, yet a large proportion of those treated do not get better. Patients with FNDs are often misdiagnosed and suffer from stigma, dysfunctional medical encounters and scarcity of adequate treatments. In this paper we argue that an anthropological understanding of these phenomena is needed for improving diagnosis and therapies. We argue that cultural meaning is pivotal in the development of FND on three levels. 1) The embodiment of cultural models, as shared representations and beliefs about illnesses shape the manifestation of symptoms and the meanings of sensations; 2) The socialization of personal trauma and chronic stress, as the way in which individuals are socially primed to cope or to reframe personal trauma and chronic stress affects bodily symptoms; 3) Moral judgment, as stigma and ethical evaluations of symptoms impact coping abilities and resilience. In particular, we focus on the disorder known as PNES (Psychogenic-Non-Epileptic Seizure) to show how cultural meaning co-determines the development...
In conclusion, variants in NGLY1 affect mitochondrial energy metabolism which in turn might contribute to the clinical disease course. This article is protected by copyright. All rights reserved. PMID: 31957011 [PubMed - as supplied by publisher]
CONCLUSIONS: Adjunctive treatment with perampanel was efficacious and tolerated in pediatric patients aged 4 years or older with epilepsy. Early perampanel treatment may help to reduce the burden of their seizures and improve their quality of life. PMID: 31942758 [PubMed]
Sometimes the best goals are soft and squishy like an eggnog filled belly.It’s either very late or very early, depending on your point of view. Either way, I’m sitting here thinking deep, New Year’s-like thoughts. In the other room sleeps a friend who almost wasn’t my friend anymore until we patched things last week. Upstairs sleeps my third daughter whose heart is in need of mending as her marriage comes to an end. Hanging out with dad and his friend on New Year’s Eve was either a low point for her or just exactly what she needed.My thoughts are a warm blend of nostalgia and regret with a sub...
Epilepsy that develops following traumatic brain injury (TBI) significantly increases the risk for disability and boosts healthcare costs, new research suggests.Medscape Medical News
Maxwell Freed, two, from Denver, Colorado is suffering from a rare genetic disorder that causes serious speech, motor and intellectual disabilities and eventually a severe form of epilepsy.
ConclusionWhile collection of the opinions of physicians is valuable, this is just one piece of the puzzle; future studies should investigate the opinions of other stakeholders. More importantly, investigators should explore whether patients with PNES have any job-related difficulties.
In conclusion, school-aged children with CP very often screened positive for ASD and/or ADHD. The prevalence of ASD and ADHD is most likely underestimated in children with CP. These screening findings require further investigations.
CONCLUSION: While collection of the opinions of physicians is valuable, this is just one piece of the puzzle; future studies should investigate the opinions of other stakeholders. More importantly, investigators should explore whether patients with PNES have any job-related difficulties. PMID: 31937514 [PubMed - as supplied by publisher]
ConclusionThe pooled estimated prevalence of headache among patients with epilepsy was considerably high (48.4%). Screening and appropriate management of headaches among patients with epilepsy are warranted.
Loss-of-function SYNGAP1 mutations cause a neurodevelopmental disorder characterized by intellectual disability and epilepsy. SYNGAP1 is a Ras-GTPase-activating protein that underlies the formation and experience-dependent regulation of postsynaptic densities. The mechanisms that contribute to this proposed monogenic cause of intellectual disability and epilepsy remain unresolved.