Cannabis-based products for pediatric epilepsy: An updated systematic review

ConclusionNewly available evidence supports earlier findings that cannabidiol probably reduces the frequency of seizures among children with drug-resistant epilepsy.PROSPEROCRD42018084755
Source: Seizure - Category: Neurology Source Type: research

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ConclusionsA wearable EEG device with 2 bipolar channels simplifies the process of obtaining repeated SI quantification allowing a more accurate follow-up of spike activity in the clinical setting.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: March 2020Source: Epilepsy &Behavior, Volume 104, Part AAuthor(s): Diana Paardekooper, Zoe Thayer, Laurie Miller, Armin Nikpour, Michael B GascoigneAbstractSleep difficulties are commonly reported by patients with epilepsy and can have a detrimental impact on overall quality of life. The purpose of this pilot study was to assess the efficacy of a psychotherapeutic approach, namely Cognitive Behavioral Therapy for Insomnia (CBT-I), in improving sleep quality in patients with epilepsy. Twenty outpatients with epilepsy who reported poor sleep quality were randomized to either a control or CBT-I treatment...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: March 2020Source: Epilepsy &Behavior, Volume 104, Part AAuthor(s): Jeffrey Do, Richard J. Webster, Patricia E. Longmuir, Sara Ieradi, Deepti Reddy, Sharon Whiting, Daniela PohlAbstractObjectiveThe aim of this study was to longitudinally characterize in children with epilepsy the objective and subjective sleep quality and the relationship between increased physical activity and sleep as well as measures of psychosocial well-being.MethodsBaseline physical activity and sleep were established in children with epilepsy over four weeks, prior to a 12-week exercise intervention (weekly meeting with exercise ...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 17 January 2020Source: Neuroscience ResearchAuthor(s): Zhaofa Wu, Yulong LiAbstractPurinergic transmitters such as adenosine, ADP, ATP, UTP, and UDP-glucose play important roles in a wide range of physiological processes, including the sleep-wake cycle, learning and memory, cardiovascular function, and the immune response. Moreover, impaired purinergic signaling has been implicated in various pathological conditions such as pain, migraine, epilepsy, and drug addiction. Examining the function of purinergic transmission in both health and disease requires direct, sensitive, non-invasive too...
Source: Neuroscience Research - Category: Neuroscience Source Type: research
Sometimes the best goals are soft and squishy like an eggnog filled belly.It’s either very late or very early, depending on your point of view. Either way, I’m sitting here thinking deep, New Year’s-like thoughts. In the other room sleeps a friend who almost wasn’t my friend anymore until we patched things last week. Upstairs sleeps my third daughter whose heart is in need of mending as her marriage comes to an end. Hanging out with dad and his friend on New Year’s Eve was either a low point for her or just exactly what she needed.My thoughts are a warm blend of nostalgia and regret with a sub...
Source: The Splintered Mind by Douglas Cootey - Category: Psychiatry Tags: ADHD Depression Family Goodreads Journaling Source Type: blogs
Abstract OBJECTIVE: The aim of this study was to longitudinally characterize in children with epilepsy the objective and subjective sleep quality and the relationship between increased physical activity and sleep as well as measures of psychosocial well-being. METHODS: Baseline physical activity and sleep were established in children with epilepsy over four weeks, prior to a 12-week exercise intervention (weekly meeting with exercise counselor). Participants continuously wore a wrist pedometer (Fitbit Flex®) to capture daily number of steps, sleep efficiency, and total sleep time. The Early Childhood Epil...
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
Journal of Clinical Sleep Medicine, Ahead of Print.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Authors: Source Type: research
Conclusions: Resective surgery is an effective treatment for selected cases of ESES, producing long term seizure freedom, resolution of ESES and stabilization of cognitive and behavioral functioning in most patients. Our case series is the largest single center cohort description addressing resective surgery for ESES. Outcomes in this sample suggest that good long-term seizure, EEG and cognitive/behavioral outcomes can be achieved in patients with normal brain imaging and in limited lobar or multi-lobar resections. Moreover, patients with ESES and very infrequent clinical seizures can benefit from surgery with stabilizatio...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Companies have unleashed hundreds of CBD pet health products accompanied by glowing customer testimonials claiming the cannabis derivative produced calmer, quieter and pain-free dogs and cats. But some of these products are all bark and no bite. “You’d be astounded by the analysis we’ve seen of products on the shelf with virtually no CBD in them,” said Cornell University veterinary researcher Joseph Wakshlag, who studies therapeutic uses for the compound. “Or products with 2 milligrams per milliliter, when an effective concentration would be between 25 and 75 milligrams per milliliter. There a...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized animals onetime Source Type: news
Abstract Autistic epileptiform regression is an uncommon but extensively described malady in children. The clinico-etiological spectrum of this entity ranges from electrical status epilepticus in sleep to various neurogenetic and neurodegenerative disorders. Identification of these disorders is crucial considering their therapeutic and prognostic implications. Simple investigations such as neuroimaging and electroencephalography with activation procedures can provide valuable diagnostic clues in resource-limited settings; facilitating targeted genetic/metabolic testing. Here we report a 3.5-year-old girl with auti...
Source: Clinical EEG and Neuroscience - Category: Neuroscience Authors: Tags: Clin EEG Neurosci Source Type: research
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