ABO blood group influences risk of venous thromboembolism and myocardial infarction

AbstractABO blood group has been associated with various disease phenotypes. However, ABO blood group to influence patients in risk of venous thromboembolic events (VTEs) and arterial thromboembolic events (ATEs) remains controversial after evaluation in several reports. To fully assess effects of ABO blood group on VTEs and ATEs, we conducted a cross-sectional study and investigated the interaction between blood group and age, and between blood group and sex on the prevalence of VTEs and ATEs. In addition, the effect of blood group on ATEs in patients with atrial fibrillation (AF) was observed. Detailed information of 7830 patients was collected. Multivariate logistic regression analyses were used to evaluate the association between blood group and VTEs, pulmonary embolism (PE) and myocardial infarction (MI). In those 7830 patients, the respective risk of VTEs and PE was higher for patients with blood group A compared with blood group O individually. In those 6713 patients with rheumatic heart disease, cardiomyopathy, myocarditis, constrictive pericarditis, or valvular heart disease excluded, blood group A was associated with the risk of MI. For VTEs, PE, and MI, blood group also exhibited significant interactions with sex and age, although there was no evidence of interaction between blood group and age for VTEs. In addition, interactions among blood group, age, and AF for the ATEs were observed. Similar to prior population studies an association of ABO blood group with sus...
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research

Related Links:

Authors: Jahołkowski P, Niewiadomska J, Wciórka J, Kowalski M, Świtaj P Abstract Clozapine, atypical antipsychotic drug, is widely used in patients with schizophrenia, for whom previous therapy was inadequate or not tolerated. Clozapine-induced myocarditis (CIM) is a relatively rare but potentially life-threatening complication of clozapine therapy; however, the underlying mechanism has not been so far well elucidated. Factors predisposing to CIM include a rapid dose titration, advanced age and co-administration of sodium valproate. In this paper, we present a case of a 22-year-old male patient with refrac...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
CONCLUSIONS: Because of ahigh risk of interactions and related adverse effects, especially in older patients, each decision regarding combination of a particular antidepressant with a medication used in treatment of cardiovascular disorders should be preceded by a detailed analysis of safety and risk-benefit ratio, and also be associated with the search for the safest, alternative combinations of the above-mentioned medications. PMID: 31955180 [PubMed - in process]
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
HOW TO live longer: Exercise can reduce your risk of major illnesses, including heart disease, stroke, type 2 diabetes and cancer, but which exercise is considered best? One study compared whether walking, running or swimming has the most life-boosting effect.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
The objective of this study was to analyze studies on animals that had exercised prior to myocardial infarction and to examine any benefits through a systematic review and meta-analysis. The databases MEDLINE, Google Scholar, and Cochrane were consulted. We analyzed articles published between January 1978 and November 2018. From a total of 858 articles, 13 manuscripts were selected in this review. When animals exercised before experimental infarction, there was a reduction in mortality, a reduction in infarct size, improvements in cardiac function, and a better molecular balance between genes and proteins that exhibit card...
Source: Clinics - Category: General Medicine Source Type: research
This study investigated the cardioprotective effect of vitexin against MIRI and its possible mechanism. Isolated SD rat hearts were subjected to MIRI in a Langendorff perfusion system, and H9c2 cells were subjected to hypoxia/reoxygenation (H/R) in vitro. Ex vivo experiments showed improved left ventricular function and reduced infarct size in the vitexin group. Transmission electron microscopy showed that I/R caused outer mitochondrial membrane rupture, cristae disappearance and vacuolation, while vitexin reduced mitochondrial damage and ultimately reduced cardiomyocyte apoptosis. In vitro, vitexin protected H9c2 cells fr...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
BOSTON (CBS) — Marijuana use is growing in popularity and local doctors are sounding the alarm about the potential harms the drug could have on the heart. They say marijuana carries many of the same cardiovascular risks as smoking tobacco. Researchers at Brigham and Women’s Hospital say while more patients are curbing their use of cigarettes, there has been an acceleration in marijuana use that marijuana users are now exceeding cigarette smokers. And the effects of the drug on cardiovascular health are not fully understood. Some studies have linked marijuana use with stroke, arrhythmias, and other heart conditi...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Seen On WBZ-TV Syndicated CBSN Boston Syndicated Local Dr. Mallika Marshall Marijuana Source Type: news
Source: Core Evidence - Category: Drugs & Pharmacology Tags: Core Evidence Source Type: research
More than two million Americans with heart disease are using or have used marijuana - and it could put them at risk of dangerously bleeding or liver damage, a Brigham and Women's study warns.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
A new study, led by Yale University, found that every time the number of ultrafine particles in the air increased, the risk of a non-fatal heart attack six hours late rose by 3.27 percent.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
In this study, there was no increased risk of adverse outcomes (including muscle aches, liver dysfunction, new onset of diabetes, cancer, and bleeding strokes), even when LDL was lowered to as low as 20 mg/dL. Although statin medications themselves have been linked to side effects, especially at high doses, it appears that extremely low LDL concentrations are not responsible for side effects. In other words, lowering LDL beyond our previous target of 70 mg/dL appears to be not only safe but beneficial, in patients with CVD. The post LDL cholesterol: How low can you (safely) go? appeared first on Harvard Health Blog.
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Drugs and Supplements Health Heart Health Source Type: blogs
More News: Atrial Fibrillation | Cardiology | Cardiomyopathy | Heart | Heart Attack | Heart Disease | Hematology | Myocarditis | Pericarditis | Pulmonary Thromboembolism | Rheumatology | Study | Thrombosis