Supramolecular Amphiphiles of Beta-Cyclodextrin and Oleylamine for enhancement of Vancomycin delivery

Publication date: Available online 9 December 2019Source: International Journal of PharmaceuticsAuthor(s): Mohammed Salih, Calvin A. Omolo, Nikhil Agrawal, Pavan Walvekar, Ayman Y. Waddad, Chunderika Mocktar, Charlotte Ramdhin, Thirumala GovenderAbstractThe global threat of antimicrobial resistant strains calls for innovative strategies to utilize nano drug delivery systems to enhance the delivery of antibiotics, thus reducing the development of resistance. Supramolecular amphiphiles that can self-assemble into nanostructures are one such nano delivery system, that are showing potential for effective drug delivery. The aim of this study was to synthesize and formulate a novel sugar-based cationic amphiphile (BCD-OLA) derivative from a Beta-cyclodextrin (BCD) head and long C18 carbon chain with a terminal amine; oleylamine (OLA), using inclusion complexation for application in antibiotic delivery. A suspension method was used for preparing the BCD-OLA amphiphile, which was then utilized for the formulation of nanovesicles. The complexation of BCD-OLA was confirmed by FTIR, 1H NMR, 2D NMR NOESY spectrum and molecular dynamic (MD) simulations. Thereafter, biosafety was evaluated using the in vitro MTT cytotoxicity assay. Size, zeta potential (ZP), polydispersity index (PDI), entrapment efficiency, in vitro drug release and antimicrobial activity of BCD-OLA-loaded nanovesicles was also evaluated. MD of the BCD-OLA simulation showed that the mechanism responsible for amphiphile fo...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research