Supramolecular Amphiphiles of Beta-Cyclodextrin and Oleylamine for enhancement of Vancomycin delivery

Publication date: Available online 9 December 2019Source: International Journal of PharmaceuticsAuthor(s): Mohammed Salih, Calvin A. Omolo, Nikhil Agrawal, Pavan Walvekar, Ayman Y. Waddad, Chunderika Mocktar, Charlotte Ramdhin, Thirumala GovenderAbstractThe global threat of antimicrobial resistant strains calls for innovative strategies to utilize nano drug delivery systems to enhance the delivery of antibiotics, thus reducing the development of resistance. Supramolecular amphiphiles that can self-assemble into nanostructures are one such nano delivery system, that are showing potential for effective drug delivery. The aim of this study was to synthesize and formulate a novel sugar-based cationic amphiphile (BCD-OLA) derivative from a Beta-cyclodextrin (BCD) head and long C18 carbon chain with a terminal amine; oleylamine (OLA), using inclusion complexation for application in antibiotic delivery. A suspension method was used for preparing the BCD-OLA amphiphile, which was then utilized for the formulation of nanovesicles. The complexation of BCD-OLA was confirmed by FTIR, 1H NMR, 2D NMR NOESY spectrum and molecular dynamic (MD) simulations. Thereafter, biosafety was evaluated using the in vitro MTT cytotoxicity assay. Size, zeta potential (ZP), polydispersity index (PDI), entrapment efficiency, in vitro drug release and antimicrobial activity of BCD-OLA-loaded nanovesicles was also evaluated. MD of the BCD-OLA simulation showed that the mechanism responsible for amphiphile fo...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

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Increased prevalence of antibiotic resistance in skin and soft tissue infections is a concerning public health challenge currently facing medical science. A combinatory, broad spectrum biocidal antiseptic has been developed (“ASP”) as a topically applied solution to potential resistant and polymicrobial infected wounds that may be encountered in this context. The ASP-105 designate was evaluated in vitro by determining the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC), against different strains of methicillin-resistant Staphylococcus aureus (MRSA), resulting estimates of whi...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: Available online 20 January 2020Source: LWTAuthor(s): Haiying Cui, Chenghui Zhang, Changzhu Li, Lin LinAbstractIn recent years, studies have found that in addition to nosocomial infections, methicillin-resistant Staphylococcus aureus (MRSA) can even cause community-associated infections, and MRSA spreads through food and animal that produce products in the community. In addition, MRSA can colonize the surface of food and food container and form biofilms by secreting extracellular polymers, leading to cross-infection. Cardamom essential oil has been found to be highly active against MRSA. Therefore, this s...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
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Source: JAMA - Category: General Medicine Source Type: research
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Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
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Source: Guardian Unlimited Science - Category: Science Authors: Tags: Drug resistance Antibiotics Medical research Cannabis Science UK news Source Type: news
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Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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Source: World Journal of Microbiology and Biotechnology - Category: Microbiology Source Type: research
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Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
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Source: The Economic Times Healthcare and Biotech News - Category: Pharmaceuticals Source Type: news
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Source: Proteomics - Category: Biochemistry Authors: Tags: Dataset Brief Source Type: research
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