Cancers, Vol. 11, Pages 1981: The Hidden Story of Heterogeneous B-raf V600E Mutation Quantitative Protein Expression in Metastatic Melanoma —Association with Clinical Outcome and Tumor Phenotypes

This study provides evidence that a higher level of expression in the mutated protein is associated with a more aggressive tumor progression. Our study design, comprised of surgical isolation of tumors, histopathological characterization, tissue biobanking, and protein analysis, may enable the eventual delineation of patient responders/non-responders and subsequent therapy for malignant melanoma.

Source: Cancers - December 8, 2019 Category: Cancer & Oncology Authors: Lazaro Hiram Betancourt A. Marcell Szasz Magdalena Kuras Jimmy Rodriguez Murillo Yutaka Sugihara Indira Pla Zsolt Horvath Krzysztof Paw łowski Melinda Rezeli Kenichi Miharada Jeovanis Gil Jonatan Eriksson Roger Appelqvist Tasso Miliotis Bo Baldetorp Chri Tags: Article Source Type: research