Integrin α6 signaling induces STAT3-TET3-mediated hydroxymethylation of genes critical for maintenance of glioma stem cells

Oncogene, Published online: 09 December 2019; doi:10.1038/s41388-019-1134-6Integrin α6 signaling induces STAT3-TET3-mediated hydroxymethylation of genes critical for maintenance of glioma stem cells
Source: Oncogene - Category: Cancer & Oncology Authors: Source Type: research

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Authors: Oshita J, Okazaki T, Mitsuhara T, Imura T, Nakagawa K, Otsuka T, Kurose T, Tamura T, Abiko M, Takeda M, Kawahara Y, Yuge L, Kurisu K Abstract We analyzed the cell characteristics, neuroprotective, and transplantation effects of human cranial bone-derived mesenchymal stem cells (hcMSCs) in ischemic stroke model rats compared with human iliac bone-derived mesenchymal stem cells (hiMSCs). The expressions of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF ) as neurotrophic factors were analyzed in both MSCs. hiMSCs or hcMSCs were intravenously administered into ischemic st...
Source: Neurologia Medico-Chirurgica - Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research
AbstractIn the pediatric population, brain tumors represent the most commonly diagnosed solid neoplasms and the leading cause of cancer-related deaths globally. They include low-grade gliomas (LGGs), medulloblastomas (MBs), and other embryonal, ependymal, and neuroectodermal tumors. The mainstay of treatment for most brain tumors includes surgical intervention, radiation therapy, and chemotherapy. However, resistance to conventional therapy is widespread, which contributes to the high mortality rates reported and lack of improvement in patient survival despite advancement in therapeutic research. This has been attributed t...
Source: Cancer and Metastasis Reviews - Category: Cancer & Oncology Source Type: research
Authors: Ravanpay AC, Gust J, Johnson AJ, Rolczynski LS, Cecchini M, Chang CA, Hoglund VJ, Mukherjee R, Vitanza NA, Orentas RJ, Jensen MC Abstract Targeting solid tumor antigens with chimeric antigen receptor (CAR) T cell therapy requires tumor specificity and tolerance toward variability in antigen expression levels. Given the relative paucity of unique cell surface proteins on tumor cells for CAR targeting, we have focused on identifying tumor-specific epitopes that arise as a consequence of target protein posttranslational modification. We designed a CAR using a mAb806-based binder, which recognizes tumor-specif...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
In this study, we discover that NRF2 also propels tumorigenesis in gliomas and glioblastomas by inducing the expression of the transcriptional co-activator TAZ, a protein of the Hippo signaling pathway that promotes tumor growth. The expression of the genes encoding NRF2 (NFE2L2) and TAZ (WWTR1) showed a positive correlation in 721 gliomas from The Cancer Genome Atlas database. Moreover, NRF2 and TAZ protein levels also correlated in immunohistochemical tissue arrays of glioblastomas. Genetic knock-down of NRF2 decreased, while NRF2 overexpression or chemical activation with sulforaphane, increased TAZ transcript and prote...
Source: Redox Biology - Category: Biology Source Type: research
This study reports an effective therapeutic platform based on MSC loaded with poly (lactic-co-glycolic acid)/black phosphorus quantum dots (PLGA/BPQDs) for targeted photothermal therapy of U251 glioma tumor cells. PLGA/BPQDs could not only be effectively uptaken by the MSC, but also stably maintained in the MSC for as long as 3 d. PLGA/BPQDs-loaded MSC exhibited changeless high tumor-tropic ability due to the exceptional biocompatibility of PLGA/BPQDs. In vitro results showed that PLGA/BPQDs can be transported from MSC to U251 cells, where U251 cells are killed after irradiation. In vivo results demonstrated that MSC@...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Abstract Considering the importance of gene expression studies for understanding the biology of glioma stem cells (GSCs), we aimed to identify the reliable reference genes in GSCs that were derived from the glioma cell lines T98G, LN229, 090116 and 091214. Quantitative real-time reverse-transcription PCR was employed using 11 reference genes identified through a PubMed literature search, and the assessment of stability through the geNorm, Normfinder and coefficient of variation methods was performed to select suitable reference genes. We found that HPRT1 and RPL13A were the most suitable reference genes, and valid...
Source: BioTechniques - Category: Biotechnology Authors: Tags: Biotechniques Source Type: research
Tumor angiogenesis is vital for tumor growth. Recent evidence indicated that bone marrow-derived mesenchymal stem cells (BMSCs) can migrate to tumor sites and exert critical effects on tumor growth through dir...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
Contributors : Rocco D Lucero ; Valentina Zappulli ; Alessandro Sammarco ; Oscar D Murillo ; Pike S Cheah ; Srimeenakshi Srinivasan ; Eric Tai ; David T Ting ; Zhiyun Wei ; Matthew E Roth ; Louise C Laurent ; Anna M Krichevsky ; Xandra O Breakefield ; Aleksandar MilosavljevicSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensGlioblastoma multiforme (GBM) is characterized by the close relationship of glioma stem cells (GSC) with aberrant vascularization. It has been established that GSC-derived extracellular vesicles (GSC-EVs) and their cargoes are proangiogenic in vitro. To elucidate...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Rocco D Lucero ; Valentina Zappulli ; Alessandro Sammarco ; Oscar D Murillo ; Pike S Cheah ; Srimeenakshi Srinivasan ; Eric Tai ; David T Ting ; Zhiyun Wei ; Matthew E Roth ; Louise C Laurent ; Anna M Krichevsky ; Xandra O Breakefield ; Aleksandar MilosavljevicSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGlioblastoma multiforme (GBM) is characterized by the close relationship of glioma stem cells (GSC) with aberrant vascularization. It has been established that GSC-derived extracellular vesicles (GSC-EVs) and their cargoes are proangiogenic in vitro. To elucidate gen...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Rocco D Lucero ; Valentina Zappulli ; Xandra O Breakefield ; Aleksandar MilosavljevicSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensGlioblastoma multiforme (GBM) is characterized by the close relationship of glioma stem cells (GSC) with aberrant vascularization. It has been established that GSC-derived extracellular vesicles (GSC-EVs) and their cargoes are proangiogenic in vitro. To elucidate gene regulatory mechanisms of neovascularization both in vitro and in vivo, we performed RNA-seq and DNA methylation profiling of the response of human brain endothelial cells to GSC-EV...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Methylation profiling by genome tiling array Homo sapiens Source Type: research
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