Severe Acute Kidney Injury Due to Nivolumab/Ipilimumab-induced Granulomatosis and Fibrinoid Vascular Necrosis

Immune-checkpoint inhibitors have revolutionized the treatment of cancers in recent years. Four drugs have obtained FDA approval in a variety of cancer types. Immune-related adverse events are common and occur in up to 60% of treated patients. Common manifestations of immune-related adverse events include rash, colitis, hepatitis, and hypophysitis. Most cases are mild to moderate in grade; however, severe manifestations with lethal outcomes have been described. Acute kidney injury is reported as a rare complication. In this case report, we present a patient with metastatic melanoma undergoing combined immune-checkpoint inhibitor therapy and displaying multiple immune-related adverse events. Despite receiving systemic steroid therapy for extrarenal immune-related adverse events, the patient developed acute progressive kidney injury requiring renal replacement therapy. Findings on renal biopsy included granulomatous interstitial nephritis, vasculitis, and thrombotic microangiopathy–like lesions. This case indicates that, although severe acute kidney injury is a rare complication of immune-checkpoint inhibitors, fulminant cases do occur and can be resistant to therapeutic intervention.
Source: Journal of Immunotherapy - Category: Allergy & Immunology Tags: Clinical Studies Source Type: research

Related Links:

Publication date: April 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 188Author(s): Didem Cetin, Meltem Okan, Erhan Bat, Haluk KulahAbstractDetection of circulating tumor cells (CTCs) from the bloodstream holds great importance to diagnose cancer at early stages. However, CTCs being extremely rare in blood makes them difficult to reach. In this paper, we introduced different surface modification techniques for the enrichment and detection of MCF-7 in microfluidic biosensor applications using gold surface and EpCAM antibody. Mainly, two different mechanisms were employed to immobilize the antibodies; covalent b...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: 25 March 2020Source: Journal of Industrial and Engineering Chemistry, Volume 83Author(s): Xuan Thang Cao, Maheshkumar Prakash Patil, Quoc Thang Phan, Cuong M.Q. Le, Byung-Hyun Ahn, Gun-Do Kim, Kwon Taek LimAbstractThis paper reports a green and direct functionalization of poly(ethylene glycol)-graft-[furfuryl-graft-(poly(styrene-alt-maleic anhydride))] (PEG-PSMF) on the surface of single walled carbon nanotubes (SWCNTs) in aqueous media through Diels-Alder (DA) click reaction. Firstly, novel PEG grafted, furfuryl functionalized copolymers were prepared by RAFT polymerization followed by ring opening react...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
Publication date: Available online 25 January 2020Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Yan Li, Shuai Wang, Fang Xiang Song, Li Zhang, Wei Yang, Hong Xia Wang, Qian Lin ChenAbstractMesoporous silica nanoparticles with folic acid (MSN-COOH-Tet-HBP-FA) are able to mediate targeting and have a pH stimulation response character, and therefore have been successfully synthesized as vectors for antitumor drug delivery. The model drug is tetrandrine (Tet). The chemical structure and properties of these NPs were characterized through systematic characterization analyses. Their drug loadi...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9NJ05860E, PaperFan Gao, Fei Wang, Xuan Nie, Ze Zhang, Guang Chen, Lei Xia, Long-Hai Wang, Chang-Hui Wang, Zong-Yao Hao, Wen-Jian Zhang, Chun-Yan Hong, Ye-Zi You Mitochondrial malfunction is considered to be a decisive signal of apoptosis. It would be a promising strategy to target mitochondria in cancer cells to generate reactive oxygen species (ROS) directly... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Publication date: Available online 25 January 2020Source: Journal of Vascular Surgery: Venous and Lymphatic DisordersAuthor(s): Steven M. Dean, Elizabeth Valenti, Karen Hock, Julie Leffler, Amy Compston, William T. AbrahamAbstractBackgroundLower extremity lymphedema is frequently encountered in the vascular clinic. Established dogma purports that cancer is the most common cause of lower extremity lymphedema in Western countries, whereas chronic venous insufficiency (CVI) is often overlooked as a potential cause. Moreover, lymphedema is typically ascribed to a single cause, yet multiple causes can coexist.MethodsA 3-year re...
Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders - Category: Surgery Source Type: research
Publication date: Available online 25 January 2020Source: Journal of Advanced ResearchAuthor(s): Bing Wei, Fei Dong, Wei Yang, Chunhua Luo, Qiujing Dong, Zuoqin Zhou, Zheng Yang, Liangquan ShengAbstractFor facilitating theranostic nanoplatform with multimodal therapeutic ability, we develop the core-shell structured CDs@SiO2@TiO2 nanoplatforms (CST NPs). The designed CST NPs possess excellent photothermal effect and fluorescence resonance energy transfer (FRET) induced photodynamic property, which could achieve synergistic photothermal and photodynamic therapy. Meanwhile, the photothermal ability of CST NPs acts as a key r...
Source: Journal of Advanced Research - Category: Research Source Type: research
ConclusionOur results suggest improved detection of PCa with similar PPV and confidence scores when higher TE values are utilized for T2-weighted image acquisition.
Source: Academic Radiology - Category: Radiology Source Type: research
Publication date: Available online 25 December 2019Source: The Journal of Molecular DiagnosticsAuthor(s): Maribel González-Acosta, Inga Hinrichsen, Anna Fernández, Conxi Lázaro, Marta Pineda, Guido Plotz, Gabriel CapelláA significant proportion of DNA-mismatch repair (MMR) variants are classified as of unknown significance, precluding diagnosis. The in vitro MMR assay is used to assess their MMR capability, likely the most important function of an MMR protein. However, the robustness of the assay, crucial for its use in the clinical setting, has been rarely evaluated. The aim of the present...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
.
Source: Neuro-Ophthalmology - Category: Opthalmology Authors: Source Type: research
Authors: Freier D, Strehl C, Buttgereit F Abstract Glucocorticoids (GC) have been proven drug substances in rheumatology for more than 70 years. They act very rapidly in high doses through membrane stabilizing effects. Genomic therapeutic effects of GC even in very low doses are mainly due to inhibition of the functions of the transcription factor nuclear factor kappa B (NFkB), which promotes the synthesis of proinflammatory mediators, adhesion molecules and other regulatory proteins. Indications for the use of GC in high doses in rheumatology are always given when a life-threatening, dangerous or tr...
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research
More News: Allergy & Immunology | Cancer | Cancer & Oncology | Hepatitis | Immunotherapy | Melanoma | Nephritis | Skin Cancer | Steroid Therapy | Study | Urology & Nephrology | Vasculitis | Yervoy