Venous thromboembolism prophylaxis in obese, critically-ill patients: A survey of Ottawa region intensivists

Up to 20% of adult intensive care unit (ICU) patients may be categorized as obese [1]. They are at increased risk of morbidity and mortality from obesity-associated comorbidities. Additionally, they have significantly altered pharmacodynamics (PD) and pharmacokinetics (PK). Venous thromboembolism (VTE) is an example of an obesity-associated comorbidity where altered PK/PD may adversely impact efficacy of VTE prophylaxis and/or treatment. During critical illness, obesity increases the risk of VTE consequent to activation of cytokines and proangiogenic factors, creating a pro-thrombotic state and dysfunctional fibrinolytic state [2].

Source: Thrombosis Research - December 7, 2019 Category: Hematology Authors: A. Frenette, B. Gershkovich, L.A. Castellucci, R.V. Patel Tags: Letter to the Editors-in-Chief Source Type: research