Two-Year Integrated Efficacy And Safety Analysis Of Benralizumab In Severe Asthma
Publication date: Available online 23 January 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Cindy L.J. Weinstein, Nicholas Ryan, Xiaoli Zhang, Tulin Shekar, Davis Gates, Stephen J. Lane, Ioana Agache, Robert A. Nathan, SPIRO InvestigatorsAbstractBackgroundDue to historical safety concerns with use of long-acting beta agonists in asthma, step-down from inhaled corticosteroid/long-acting beta agonist (ICS/LABA) combination therapy to ICS monotherapy is recommended once asthma control is achieved.ObjectiveTo evaluate the benefit/risk question about whether asthma patients who achieve diseas...
Publication date: Available online 22 January 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Nicola A. Hanania, Ratko Djukanovic, Liam G. Heaney, Ming Yang, Bongin Yoo, Ahmar Iqbal, Noelle M. Griffin, Bradley E. Chipps
ConclusionsThe clinical phenotype of asthma that persists from childhood to adulthood seems to be a distinct phenotype of adult asthma.
Background Airway obstruction and wheezing in preschool children with recurrent viral infections are a major clinical problem, and are recognised as a risk factor for the development of chronic asthma. We aimed to analyse whether gene expression profiling provides evidence for pathways that delineate distinct groups of children with wheeze, and in combination with clinical information could contribute to diagnosis and prognosis of disease development. Methods We analysed leukocyte transcriptomes from preschool children (6 months–3 years) at acute wheeze (n=107), and at a revisit 2–3 months later...
How does climate change threaten the health and survival of humans? Beyond obvious threats like heatstroke, doctors and other scientists suspect climate change factored in the 2012 Dallas epidemic of West Nile encephalitis and the spread of other tropical diseases shared by mosquitos. One physician expert points to climate change as a contributing factor for allergies, asthma, worse COPD conditions, and heart attacks. Physicians will address this timely issue and more during the 2020 Texas Medical Association (TMA) Winter Conference in Austin this week.
ConclusionWe did not observe an increased risk of pregnancy losses or malformations among women with asthma. However, we found an association between asthma severity and SGA; and between exacerbations late in pregnancy and preterm delivery and NICU admission.
This article provides highlights of the clinically impactful original studies and reviews published in The Journal of Allergy and Clinical Immunology: In Practice in 2019 on the subjects of anaphylaxis, asthma, dermatitis, drug allergy, food allergy, immunodeficiency, immunotherapy, rhinitis/sinusitis, and urticaria/angioedema/mast cell disorders. Within each topic, practical aspects of diagnosis and management are emphasized. Treatments discussed include lifestyle modifications, allergen avoidance therapy, positive and negative effects of pharmacologic therapy, and various forms of immunologic and desensitization manageme...
Hypersensitivity reactions(HSR) to chemotherapeutic agents have been increasingly documented.
Hereditary angioedema due to C1 inhibitor deficiency (HAE-C1INH) is a rare autosomal dominant disease. Patients often report prodromal symptoms that can precede the onset of a swelling attack1,2. Prodromes are frequently subjective however and attack correlation is unclear. Erythema marginatum (EM) the only objective and relatively specific prodrome for HAE-C1INH3,4 is reported in ∼40-% of HAE-C1INH patients5,6.
Urticaria is a common condition that has diverse non-allergic and allergic causes.  Its prevalence is higher in the first years of life and it decreases with age . While the majority of cases in children are thought to be triggered by infections, 50% to 60% of acute urticaria (AU) cases are considered to be idiopathic or unknown [1-3].