MicroRNA-448 modulates the progression of neuropathic pain by targeting sirtuin 1.

MicroRNA-448 modulates the progression of neuropathic pain by targeting sirtuin 1. Exp Ther Med. 2019 Dec;18(6):4665-4672 Authors: Chu Y, Ge W, Wang X Abstract MicroRNAs (miRNAs) play crucial roles in the pathogenesis of neuropathic pain. The present study investigated the effects of miR-448 on the progression of neuropathic pain in a rat model of chronic constriction injury (CCI) of the sciatic nerve. Reverse-transcription quantitative polymerase chain reaction was conducted to detect the gene expression. The paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) were used to assess the pain threshold. The protein expression levels of interleukin (IL)-6, IL-1β and tumor necrosis factor-α (TNF-α) were detected by ELISA. The target of miR-448 was predicted by TargetScan software. The Student's t-test or one-way ANOVA were used to identify statistical differences among groups. miR-448 was persistently upregulated in CCI rats, and both mechanical allodynia and thermal hyperalgesia in CCI rats were decreased following miR-448 downregulation. The expression levels of IL-1β, IL-6 and TNF-α were significantly increased in CCI rats compared with controls, and these effects were reversed following treatment with a miR-448 inhibitor. A luciferase reporter assay revealed that sirtuin 1 (SIRT1) was a target gene of miR-448. SIRT1 was found to abrogate the effect of miR-448 on neuropathic pain development. Collectively, the results...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research

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Conclusions: Valoctocogene roxaparvovec was found to be cost-saving-on average by about $6.8 million per patient-and more effective than prophylactic therapy for treatment of hemophilia A. The comparative benefit of gene therapy was observed across a broad range of simulated patients that were representative of the real-world severe hemophilia A population. PMID: 31971453 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
Opioids are commonly prescribed to manage pain in patients with IBD despite increasing evidence of harm associated with chronic use. The aim of the current study was to describe trends in opioid use among veterans with IBD.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Epidemiology Source Type: research
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Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Quality of Life/Psychosocial Care Source Type: research
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Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Quality of Life/Psychosocial Care Source Type: research
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Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
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Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
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Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Health Policy Patients caregivers carepartner Grace Cordovano Judy Faulkner patient advocacy Patient advocates Tommy Thompson Source Type: blogs
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Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
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Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
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