Pharmacokinetics and tissue distribution of four major bioactive components in rats after oral administration of Xianglian pill.

In this study, the pharmacokinetics and tissue distribution of the four alkaloids were investigated. The analytical samples were analyzed using validated HPLC-MS/MS method. The results showed that the four alkaloids could be slowly absorbed. The Cmax values of berberine, jatrorrhizin, coptisine, and palmatine were 11.420, 2.287, 2.584, 3.102 ng/mL, respectively. Subsequently, the tissue distribution studies showed that they were quickly distributed to various tissues with rich blood flow in the body.
PMID: 31808576 [PubMed - as supplied by publisher]

Source: Biomedical Chromatography : BMC - December 5, 2019 Category: Biomedical Science Authors: Lu M, Chu Z, Wang L, Liang C, Sun P, Xiong S, Mu Y Tags: Biomed Chromatogr Source Type: research