Lidocaine tripotassium phosphate complex laden microemulsion for prolonged local anaesthesia: In vitro and in vivo studies

Publication date: 1 January 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 185Author(s): Furqan A. Maulvi, Lakshmi V. Pillai, Kajal P. Patel, Ankita R. Desai, Manish R. Shukla, Ditixa T. Desai, Hetal P. Patel, Ketan M. Ranch, Shailesh A. Shah, Dinesh O. ShahAbstractLidocaine is widely used as a local anaesthetic in the clinical practice to manage pre- and post-operative pain, skin burns, etc. However, the short duration of action (
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research

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Publication date: Available online 31 December 2019Source: BurnsAuthor(s): J.L. Schiefer, A. Lipensky, P.C. Fuchs, W. Heitzmann, A. SchulzAbstractIntroductionVarious clinical studies found that enzymatic debridement (EDNX) is superior to tangential excision after severe burns. The current study evaluates patients’ satisfaction with pain management in EDNX with special respect to different anesthesia techniques.MethodsBetween 2015 and 2016, all patients at a department of plastic surgery were asked to complete a German-wide validated pain questionnaire. In a retrospective study design, satisfaction with pain managemen...
Source: Burns - Category: Dermatology Source Type: research
This article is concerned with the management of burns, which 3% of the population suffer from annually. Ketamine, acknowledged for its versatility and safety profile, remains a critical component in the medical arsenal of anaesthesiologists and clinicians treating both acute and chronic pain. In the management of burn-injured patients in particular, ketamine is the cornerstone of many analgesia protocols. However, issues pertaining to shortages of this medicine in SA warrant concern and discussion, particularly in view of the high reliance of doctors on ketamine for first-line procedural analgesia in the management of bur...
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
Authors: Plečko M, Bohaček I, Tripković B, Čimić M, Jelić M, Delimar D Abstract Anterior section of the hip joint capsule is innervated by femoral nerve and obturator nerve, and posterior section is innervated by the nerve to quadratus femoris muscle and occasionally by the superior gluteal (posterolateral region) and sciatic nerve (posterosuperior region). One of the regional anesthesia options for hip surgery is the fascia iliaca compartment block (FICB) that affects nerves important for hip innervation and sensory innervation of the thigh - femoral, obturator and lateral femoral cutaneous nerve. FICB can b...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
Police officer Charles Thomas (left) examines an Esmarch chloroform mask (similar to the museum example,right) found in November of 1933 alongside the dead body of Chicagoan Rheta Wynekoop. As the latter ’s philandering husband rode a train out of town, his cash-strapped mother, physician Alice Wynekoop (1871 to 1955), confirmed that she had already taken out extra life insurance on Rheta. When Rheta complained of abdominal pain, her mother-in-law chloroformed her “for the examination.” Panick ing when Rheta appeared to have dropped dead, Dr. Wynekoop tried to cover up the medical mishap by shooting her d...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
Abstract Lidocaine is widely used as a local anaesthetic in the clinical practice to manage pre- and post-operative pain, skin burns, etc. However, the short duration of action (
Source: Colloids and Surfaces - Category: Biotechnology Authors: Tags: Colloids Surf B Biointerfaces Source Type: research
Robert Chelsea turned down the first face he was offered. It was a fine face, one that could have taken him off the transplant waiting list after just a couple months. But Chelsea—severely disfigured after a catastrophic car accident five years earlier—was in no hurry. He’d gotten used to tilting his head back so food and water wouldn’t fall out of his nearly lipless mouth. He knew how to respond compassionately to children who stared in shock and fear. The face, offered in May 2018, had belonged to a man with skin that was much fairer than what remained of Chelsea’s—so light that Chelse...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Healthcare Source Type: news
Publication date: Available online 26 July 2019Source: Best Practice &Research Clinical AnaesthesiologyAuthor(s): Mark R. Jones, Matthew B. Novitch, O. Morgan Hall, Andrew P. Bourgeois, George M. Jeha, Rachel J. Kaye, Vwaire Orhurhu, Mariam Salisu Orhurhu, Matthew Eng, Elyse M. Cornett, Alan David KayeAbstractThe facsia iliaca block (FIB) is a relatively new regional technique where local anesthetic is delivered within the fascia iliaca region. Indications for a FIB include surgical anesthesia to the lower extremity after knee, femoral shaft, hip surgery, management of cancer pain or pain secondary to inflammatory cond...
Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research
CONCLUSION: In patients with cardiogenic shock after delivery, early transthoracic echocardiography is a non-invasive tool that can rapidly narrow the differential diagnosis. PMID: 31324480 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
Publication date: Available online 19 July 2019Source: Best Practice &Research Clinical AnaesthesiologyAuthor(s): Ivan Urits, Peter S. Ostling, Matthew B. Novitch, James C. Burns, Karina Charipova, Kyle L. Gress, Rachel J. Kaye, Matthew R. Eng, Elyse M. Cornett, Alan David KayeAbstractRegional anesthetic techniques are important components of successful multimodal analgesic strategies. When used successfully, truncal nerve blocks of the chest wall, abdomen, and, paraneuraxial nerves, in combination with other analgesic modalities, may offer similar analgesic efficacy as neuraxial techniques, which are associated with a...
Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research
Conclusions This study shows that low-dose (30-mg) dextromethorphan is antihyperalgesic in humans on the areas of primary and secondary hyperalgesia and reverses peripheral and central neuronal sensitization. Because dextromethorphan had no intrinsic antinociceptive effect in acute pain on healthy skin,N-methyl-d-aspartate receptor may need to be sensitized by pain for dextromethorphan to be effective.
Source: Anesthesiology - Category: Anesthesiology Source Type: research
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