Impact of PLA/Mg films degradation on surface physical properties and biofilm survival

Publication date: 1 January 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 185Author(s): M.Coronada Fernández-Calderón, Daniel Romero-Guzmán, Ana Ferrández-Montero, Ciro Pérez-Giraldo, Jose L. González-Carrasco, Marcela Lieblich, Rosario Benavente, Begoña Ferrari, M.Luisa González-Martín, Amparo M. Gallardo-MorenoAbstractNew biocompatible and bioabsorbable materials are currently being developed for bone regeneration. These serve as scaffolding for controlled drug release and prevent bacterial infections. Films of polylactic acid (PLA) polymers that are Mg-reinforced have demonstrated they have suitable properties and bioactive behavior for promoting the osseointegration process. However little attention has been paid to studying whether the degradation process can alter the adhesive physical properties of the biodegradable film and whether this can modify the biofilm formation capacity of pathogens. Moreover, considering that the concentration of Mg and other corrosion products may not be constant during the degradation process, the question that arises is whether these changes can have negative consequences in terms of the bacterial colonization of surfaces. Bacteria are able to react differently to the same compound, depending on its concentration in the medium and can even become stronger when threatened.In this context, physical surface parameters such as hydrophobicity, surface tension and zeta potential of PLA films reinforced with 10% Mg have been...

Source: Colloids and Surfaces B: Biointerfaces - December 8, 2019 Category: Biochemistry Source Type: research