The OPTICA Study - The Optimised Computed Tomography Pulmonary Angiography (CTPA) in Pregnancy, Quality and Safety Study

Conditions:   Pulmonary Embolism;   Pregnancy Related;   Venous Thromboembolism Intervention:   Diagnostic Test: OPTICA CTPA Protocol Sponsors:   University College Dublin;   Mater Misericordiae University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Conditions:   Pulmonary Embolism;   Pregnancy Related;   Venous Thromboembolism Intervention:   Diagnostic Test: OPTICA CTPA Protocol Sponsors:   University College Dublin;   Mater Misericordiae University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Pulmonary Embolism;   Pregnancy Related;   Venous Thromboembolism Intervention:   Diagnostic Test: OPTICA CTPA Protocol Sponsors:   University College Dublin;   Mater Misericordiae University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Pulmonary Embolism;   Pregnancy Related;   Venous Thromboembolism Intervention:   Diagnostic Test: OPTICA CTPA Protocol Sponsors:   University College Dublin;   Mater Misericordiae University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Pulmonary Embolism;   Pregnancy Related;   Venous Thromboembolism Intervention:   Diagnostic Test: OPTICA CTPA Protocol Sponsors:   University College Dublin;   Mater Misericordiae University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Pulmonary Embolism;   Pregnancy Related;   Venous Thromboembolism Intervention:   Diagnostic Test: OPTICA CTPA Protocol Sponsors:   University College Dublin;   Mater Misericordiae University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsOur method supported or altered clinical decision-making and treatment in this cohort. A diagnostic tool for PE without intravenous contrast agent or radiation is of great benefit for certain patients.
Source: European Journal of Radiology Open - Category: Radiology Source Type: research
Abstract INTRODUCTION: In the recently proposed YEARS algorithm was shown to safely exclude pulmonary embolism (PE) and reduce usage of computed-tomography pulmonary angiogram (CTPA) among pregnant women with suspected PE. Our aim was to externally validate this finding. METHODS: We performed a post-hoc analysis of a prospective management outcome study for PE diagnosis in pregnant women. PE was diagnosed using an algorithm that combined the revised Geneva Score, D-dimer test, bilateral lower limb compression ultrasonography and CTPA. All women had a 3-month follow up. All the items necessary to follow the YE...
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: J Thromb Haemost Source Type: research
CTPA is the gold standard investigation for evaluating suspected pulmonary embolism (PE) in the general population however is sometimes considered second line in pregnant and post-partum patients with a normal CXR due to its higher breast dose and the increased radio-sensitivity of breast tissue during this period. Guidelines advocating for scintigraphy over CTPA, however, quote significantly higher breast doses than those achievable with optimised low dose strategies. Defining the radiation dose achievable with a specific low-dose CTPA protocol is therefore imperative.
Source: Thrombosis Research - Category: Hematology Authors: Tags: Full Length Article Source Type: research
Conclusion: A diagnostic strategy based on assessment of clinical probability, D-dimer measurement, CUS, and CTPA can safely rule out PE in pregnant women. Primary Funding Source: Swiss National Foundation for Scientific Research, Groupe d'Etude de la Thrombose de Bretagne Occidentale, and International Society on Thrombosis and Haemostasis. PMID: 30357273 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research
This article is protected by copyright. All rights reserved. PMID: 30084149 [PubMed - as supplied by publisher]
Source: Accident and Emergency Nursing - Category: Emergency Medicine Authors: Tags: Acad Emerg Med Source Type: research
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