The Effects of a Multimodal Approach for the Treatment of Primary Progressive Aphasia
Condition: Primary Progressive Aphasia Interventions: Device: Active tDCS; Device: Placebo tDCS; Behavioral: Language training; Behavioral: Unstructured cognitive training Sponsors: IRCCS Centro San Giovanni di Dio Fatebenefratelli; Azienda Ospedaliera Spedali Civili di Brescia Not yet recruiting
ConclusionRegardless of its rarity, it is evident that damage in the left SMA usually results in a clinical syndrome that clearly corresponds to aphasia. Interpreting this as an aphasia can aid in overcoming the limited idea of a “language zone” located in the perisylvian area of the left hemisphere, that was proposed over one century ago.
An elderly woman with h/o stroke and aphasia seemed different to her daughter, and was pointing all over her body as if in pain.They called 911.She had a history of PCI to the circumflex and also of severe mitral regurgitation, status post bioprosthetic valve replacement. Also a h/o LV aneurysm with thrombus, on anticoagulation, as well as a dual chamber pacemaker. On arrival, the BP was 60/30.Here is the initial ECG:There is atrial pacing and Right Bundle Branch Block (RBBB)There is STE in I and aVL, V5, V6, with reciprocal STD in II, III, aVFThere is appropriately discordant ST depression in V1-V3 (appropriate...
Discussion:GJB1 mutations form a clinical spectrum, including most patients with peripheral nerve involvement, those with both peripheral neuropathy and CNS involvement, and patients with CNS involvement only.
A 57-year-old man with atherosclerosis obliterans was admitted with sudden-onset sensory aphasia and right hemiparesis. Brain MRI revealed acute cerebral infarctions in the left temporal lobe and magnetic resonance angiography showed occlusion of the posterior branch of the left middle cerebral artery. Transesophageal echocardiography and ultrasonography respectively confirmed a patent foramen ovale and deep vein thrombosis in the bilateral femoral veins. Blood findings showed low protein S antigen, low protein S activity, and a missense mutation of the PROS 1 gene.
CONCLUSION: Despite widespread use of rTMS, high-quality evidence for its routine use for the treatment of stroke survivors is lacking. Further studies are required to establish differential roles of various protocols and long-term effects of rTMS in the stroke population. PMID: 31922207 [PubMed - as supplied by publisher]
DISCUSSION: The global CDR plus NACC FTLD score could be an attractive outcome measure for clinical trials in symptomatic FTLD, and may be useful in natural history studies and clinical trials in FTLD spectrum disorders. PMID: 31914218 [PubMed - in process]
ConclusionsThe present study showed that the Landscape Montage Technique can be useful for diagnosing behavioral variant frontotemporal dementia that starts as logopenic variant primary progressive aphasia at earlier stages.