Effect of Insulin Resistance on the Effects of Omega-3 Acid Ethyl Esters on Left Ventricular Remodeling after Acute Myocardial Infarction (From the OMEGA-REMODEL Randomized Clinical Trial)

We reported that 6-month treatment with omega-3 fatty acid (O-3FA) 4 gm/day attenuated cardiac remodeling accompanied by reduction in inflammation. We hypothesized that insulin resistance modifies the therapeutic effect of O-3FA on post-MI cardiac remodeling. The OMEGA-REMODEL study group was dichotomized according to cohort- and gender-specific median cutoff value of leptin-to-adiponectin ratio (LAR) at baseline (LAR-Hi vs.

Source: The American Journal of Cardiology - December 6, 2019 Category: Cardiology Authors: Kana Fujikura, Bobak Heydari, Yin Ge, Kyoichi Kaneko, Shuaib Abdullah, William S. Harris, Michael Jerosch-Herold, Raymond Y. Kwong Source Type: research