Unanswered Questions in Eosinophilic Esophagitis

Eosinophilic esophagitis (EoE) is an antigen-driven disease associated with a patchy, pan-esophageal infiltration of eosinophils, mast cells, and T cells. Persistent inflammation triggers dysregulated wound healing that progresses to pathologic tissue remodeling with esophageal rigidity and clinical symptoms of dysphagia and food impactions.1 The most common complaints in adults and teenagers is dysphagia while younger children more commonly have symptoms that mimic gastroesophageal reflux disease like vomiting.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Perspective Source Type: research

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In the early 1990s, doctors began describing a new condition affecting the esophagus of patients who were predisposed to allergies including food allergy, asthma, and eczema, and who were having trouble swallowing. Today, we call this condition eosinophilic esophagitis (EoE). What is EoE? EoE is an allergic inflammation of the esophagus that causes a range of symptoms. Adolescents and adults most often experience it as difficulty swallowing, sometimes feeling like food moves too slowly through the esophagus and into the stomach. In some cases, food actually gets stuck (and may require urgent removal). Children and some adu...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Allergies Digestive Disorders Health Source Type: blogs
We examined deidentified patient data from 28,508 unique encounters documented in the Asthma Specialist Tool to Help Manage Asthma and Improve Quality database, obtaining patient-level factors (demographics, asthma characteristics, comorbidities), care setting (primary care physician [PCP] vs specialist physician [allergist or pulmonologist]), and guideline-defined levels of asthma control/severity. Rates of comorbidities were identified by asthma severity and control and by care setting. We calculated odds ratios for asthma control and severity based on each comorbidity.ResultsBaseline demographic data indicated that pati...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
This study’s goal is to compare major aspects of these two phenotypes.Methods: A retrospective study of adult patients with asthma diagnosis observed in our Asthma clinic between 2012 and 2016. Patients were divided into EOA (onset 18 years old) groups and their data was statistically analysed.Results: 606 patients were included, 351 had EOA and 233 LOA. In the EOA group, 71.2% were women (N=250), 47.3% (N=116) had smoking history and 27.1% (N=95) were obese. Rhinitis was found in 298 patients (84.9%), gastroesophageal reflux disease (GERD) in 71 (20.2%), anxiety or depression in 30 (8.5%), cardiac disease in 29 (8.2...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Conclusion: Within a pediatric primary care population, we found different patterns of drug use over age, associated with various comorbidities. This helps understanding the diversity within pediatric asthma.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric asthma and allergy Source Type: research
This study demonstrates the difficulties which arise when assigning a diagnosis of asthma to a symptomatic patient. We believe that careful assessment of airway physiology should be a cornerstone of the diagnostic process in the case of this disease.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical respiratory physiology, exercise and functional imaging Source Type: research
This study aimed to delineate the causal relation between GERD and asthma.MethodsParticipants of the Korean National Health Insurance Service-National Sample Cohort 2002-2013 who were ≥ 20 years old were selected for this study. In study I, 116,502 GERD patients were matched in a 1:2 ratio to 233,004 control I participants, and the hazard ratio (HR) of asthma in GERD patients was analyzed. In study II, 104,146 asthma patients were matched in a 1:1 ratio to 104,146 control II participants, and the HR for GERD in asthma patients was analyzed. A stratified Cox-proportional hazards model was used. Subgroup analyses were per...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
We examined de-identified patient data from 28,508 unique encounters documented in the Asthma IQ database, obtaining patient level factors (demographics, asthma characteristics, co-morbidities), care setting (primary care physician [PCP] versus specialist physician [Allergist or Pulmonologist]), and guideline-defined levels of asthma control/severity. Rates of co-morbidities were identified by asthma severity and control and by care setting. We calculated odds ratios (ORs) for asthma control and severity based on each co-morbidity.ResultsBaseline demographic data indicated that patients seen by specialists versus PCPs, wer...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
A 16-year old coed was referred for continuing care of her Idiopathic Anaphylaxis/Mast Cell Degranulation Syndrome (MCDS) soon after moving into her grandparents ’ rural home, separating her from a neighborhood boy. Her diagnoses included Gastro-esophageal Reflux and Post-Traumatic Stress Disorder for which she received Omalizumab Immunotherapy, Sertraline, Cetirizine, Fexofenadine, Montelukast, Ranitidine, Calcium, Vitamin D3 and as needed Epinephrine.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
ConclusionIn patients where surgery was performed for non-inflammatory sinus disease, turbinate resection is not correlated with poorer postoperative nasal obstruction, sinonasal function nor sleep quality.
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
Conclusions:The absence of demographic or clinical predictors of OSA supports using general indications for PSG in children with ASD.Citation:Tomkies A, Johnson RF, Shah G, Caraballo M, Evans P, Mitchell RB. Obstructive sleep apnea in children with autism.J Clin Sleep Med. 2019;15(10):1469–1476.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
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