Genital tract and reproductive characteristics in daughters of women and men prenatally exposed to diethylstilbestrol (DES).

CONCLUSION: These results must be considered as preliminary, due to the small numbers of patients, limited follow-up duration after birth due to young age of the studied population, and observational methods. An important point is that the high risk of reproductive dysfunction of women prenatally exposed to DES was not observed in their daughters. There is a signal on the high incidence of uterine defects, especially aplastic uterus, and its possible link with DES exposure through epigenetic effects is discussed in our findings. Inconsistent findings regarding pregnancy outcomes in the third generation are worthy of further examination. PMID: 31806244 [PubMed - as supplied by publisher]
Source: Therapie - Category: Psychiatry & Psychology Authors: Tags: Therapie Source Type: research

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Authors: Fournier E Abstract Carpal tunnel syndrome (CTS) is too common a condition not to daily interact with the practitioner, if only because of its entanglement to other pathologies, causal or chance association. The typical symptomatology, with hand paresthesia and morning pain upon waking, is related to a median nerve injury in the confined space of the carpal tunnel, more often by local inflammation and tenosynovitis of the finger flexors (repetitive activity of the hands). SCC may be secondary to situations (pregnancy) or conditions (edema, hypothyroidism…), which exaggerate the ordinary pathophysiol...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Publication date: April 2020Source: Safety Science, Volume 124Author(s): Ci Liang, Mohamed Ghazel, Olivier Cazier, Laurent BouillautAbstractSafety is a core issue in the railway operation. In particular, as witnessed by accident/incident statistics, railway level crossing (LX) safety is one of the most critical points in railways. In the present paper, a Bayesian network (BN) based framework for causal reasoning related to risk analysis is proposed. It consists of a set of integrated stages, namely risk scenario definition, real field data collection and processing, BN model establishment and model performance validation. ...
Source: Safety Science - Category: Occupational Health Source Type: research
Publication date: Available online 25 January 2020Source: Sensing and Bio-Sensing ResearchAuthor(s): Shirley T. Palisoc, Earl Jerald F. Cansino, Isis Maxine O. Dy, Cassandra Faith A. Razal, Kimberly Claire N. Reyes, Lotis R. Racines, Michelle T. NatividadAbstractA cost-effective and environment-friendly electrochemical sensor based on waste-battery graphite electrodes is developed. The electrodes were extracted from different brands of waste zinc‑carbon batteries and were used as the working electrode in differential pulse voltammetry (DPASV) for the electrochemical determination of tannic acid (TA). The bare graphite el...
Source: Sensing and Bio Sensing Research - Category: Research Source Type: research
France said on Sunday it expected to evacuate hundreds of its citizens from the Wuhan area in China, the epicentre of a coronavirus outbreak.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
France's government will repatriate up to hundreds of French citizens from the Chinese city of Wuhan as the new deadly virus spreads in the area
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
Publication date: Available online 25 January 2020Source: Biocybernetics and Biomedical EngineeringAuthor(s): Saqib Saleem, Ahmed Saeed, Shabnam Usman, Javed Ferzund, Jahangir Arshad, Jawad Mirza, Tareq ManzoorAbstractAccording to World Health Organization, 5—18% births around the world are premature, and this rate is on its rise. Recent trend has been to develop computational tools which could support obstetricians in their daily practice. This work is aimed at extracting novel diagnostic features for term vs. preterm births classification based on the dynamics of contraction and non-contractions (dummy) intervals. ...
Source: Biocybernetics and Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Molecular cytogenetic characterization of an isodicentric Yq and a neocentric isochromosome Yp in an azoospermic male. Mol Med Rep. 2020 Feb;21(2):918-926 Authors: Jiang Y, Yue F, Wang R, Zhang H, Li L, Li L, Li S, Liu R Abstract Isodicentric Y chromosomes are considered one of the most common structural abnormalities of the Y chromosome. Neocentric marker chromosomes, with neocentromeres, have drawn increasing attention in recent years. The present study reported an azoospermic male with a neocentric isochromosome Yp, neo(Yp), and an isodicentric Yq, idic(Yq). The ka...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
In this study, the aim was to characterize the intracellular and extracellular metabolite profiles of different oxidative stress cell models commonly used in the research of pregnancy complications. HTR8/SVneo human trophoblast cell lines were treated with five different oxidative stress‑inducing conditions: Hypoxia (1% oxygen); hypoxia and reoxygenation; cobalt chloride (CoCl2; 300 µmol/l); sodium nitroprusside (SNP; 2.5 mmol/l); and the serum of women with preeclampsia (10% v/v). Intracellular metabolites were extracted from cells and extracellular metabolites were collected from spent media for me...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
In conclusion, GDM was associated with increased placental permeability and this may be linked with changes in TJs. LMWH intervention mediated protection against this GDM‑associated shift in placental permeability via the RAGE/NF‑κB pathway. PMID: 31974593 [PubMed - in process]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Authors: Tagliaferri S, Esposito FG, Esposito G, Saccone G, Signorini MG, Magenes G, Campanile M, Guida M, Zullo F Abstract Analysing antepartum and intrapartum computerised cardiotocographic (cCTG) parameters in physiological term pregnancies with nuchal (NC) or body cord (BC), in order to correlate them with labour events and neonatal outcome. We enrolled 808 pregnant women, composed of 264 with 'one NC', 121 with 'multiple NCs', 39 with BC and 384 with 'no NC', were monitored from the 37th week of gestation before labour, while 49 pregnant women with 'one or more NCs' and 47 with 'no NCs' were analysed during la...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
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