LncRNA AWPPH promotes the invasion and migration of glioma cells through the upregulation of HIF1 α.

LncRNA AWPPH promotes the invasion and migration of glioma cells through the upregulation of HIF1α. Oncol Lett. 2019 Dec;18(6):6781-6786 Authors: Zhang T, Wang F, Liao Y, Yuan L, Zhang B Abstract Long non-coding RNA (lncRNA) AWPPH has been revealed to serve pivotal roles in bladder cancer and liver cancer. The aim of the present study was to determine the involvement of lncRNA AWPPH in glioma. It was observed in the present study that the expression levels of AWPPH in plasma were significantly higher in patients with metastatic glioma compared with those in patients with non-metastatic glioma and healthy controls. In effect, overexpression of AWPPH allowed the differentiation of patients with metastatic glioma from patients with non-metastatic glioma and in healthy controls. Increased migration and invasion rates of glioma cells and upregulated hypoxia-inducible factor 1-α (HIF1α) expression were observed following AWPPH overexpression. HIF1α overexpression exhibited no significant effects on AWPPH expression but also promoted the migration and invasion of cancer cells. HIF1α small interfering RNA silencing attenuated the enhancing effects of AWPPH overexpression on the migration and invasion of glioma cells. From the results of the present study it was concluded that AWPPH may promote glioma metastasis by serving as an upstream activator of HIF1α. PMID: 31807187 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

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lncRNA AWPPH promotes the migration and invasion of glioma cells by activating the TGF-β pathway. Oncol Lett. 2019 Dec;18(6):5923-5929 Authors: Dai B, Xiao Z, Mao B, Zhu G, Huang H, Guan F, Su H, Lin Z, Peng W, Hu Z Abstract The long noncoding RNA (lncRNA) AWPPH, also termed microRNA-4435-2HG, has been associated with the poor prognosis of patients with hepatocellular carcinoma (HCC), and has been demonstrated to promote the progression of HCC and bladder cancer. The present study aimed to investigate the role of lncRNA AWPPH in glioma. The expression levels of AWPPH in tumor tissues obtained from...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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