Effect of drug molecular weight on niosomes size and encapsulation efficiency

Publication date: Available online 6 December 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Pablo García-Manrique, Noelia D. Machado, Mariana A. Fernández, María Carmen Blanco-López, María Matos, Gemma GutiérrezAbstractEncapsulation into nanocarriers, such as niosomes, is a promising way to protect them from degradation, and allow controll and target delivery of bioactive compounds. For biotechnological applications, a tight control of particle size with acceptable encapsulation efficiencies (EE) is a technological challenge, especially for hydrophilic compounds due to its capability to diffuse across biological barriers. Niosomes formulated with mixture of surfactants represent promising nanocarriers due to the advantages of non-ionic surfactants, such as low cost, versatility and enhanced physico-chemical properties. In this work, the effect of both, composition of the hydrating solution and molecular weight of the loaded compound, on the particle size and EE of niosomes prepared by using the thin film hydration method was studied. Particularly, mili-Q water, glycerol solution and PEG-400 solution were tested for niosomes formulated with Span®80-Tween®80 with/without dodecanol as membrane stabilizer. It was found that particle size highly depends on hydration media composition and an interaction with compound MW could exist. Larger vesicles results in an increase in EE, which could be purely related with physi...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research

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ConclusionsParasternal minimally ‐invasive aortic valve replacement is a feasible technique associated with a slow learning curve but the potential to achieve improved outcomes. Considering the transcatheter alternatives, the relative risk reduction may be worth investigating in future trials.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
Redox-responsive nanoparticles from disulfide bond-linked poly-(N-ε-carbobenzyloxy-l-lysine)-grafted hyaluronan copolymers as theranostic nanoparticles for tumor-targeted MRI and chemotherapy. Int J Biol Macromol. 2020 Jan 08;: Authors: Yang H, Miao Y, Chen L, Li Z, Yang R, Xu X, Liu Z, Zhang LM, Jiang X Abstract Redox-responsive theranostic nanoparticles based on poly-(N-ε-carbobenzyloxy-l-lysine) (PZLL) grafted hyaluronan (HA) (HA-g-SS-PZLL) copolymers were constructed for hepatocellular carcinoma diagnosis and therapy. These hyaluronan derivatives formed nanoparticles via a self-ass...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
Publication date: Available online 23 December 2019Source: European Polymer JournalAuthor(s): Tatjana J. Kop, Dragica M. Jakovljević, Ljiljana S. Živković, Andrijana Žekić, Vladimir P. Beškoski, Dragana R. Milić, Gordana D. Gojgić-Cvijović, Mira S. BjelakovićAbstractAn efficient encapsulation of the fullerene into two hydrophobized and one native polysaccharide provided water soluble supramolecular hybrids. After covalent modification of polysaccharides by cholesterol, noncovalent hybrids were prepared by a three-step procedure, including mixing of individual aqueous solutions of hydrophobized, as well as n...
Source: European Polymer Journal - Category: Chemistry Source Type: research
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Source: Critical Care Medicine - Category: Emergency Medicine Tags: Clinical Investigations Source Type: research
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Source: Hong Kong Med J - Category: General Medicine Authors: Tags: Hong Kong Med J Source Type: research
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Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
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Source: Journal of Membrane Science - Category: Materials Science Source Type: research
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Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
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Source: Jornal Vascular Brasileiro - Category: Surgery Source Type: research
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Source: Canadian Urological Association Journal - Category: Urology & Nephrology Authors: Tags: Can Urol Assoc J Source Type: research
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