Gastrointestinal (Non-systemic) Antibiotic Rifaximin Differentially Affects Chronic Stress-induced Changes in Colon Microbiome and Gut Permeability without Effect on Behavior

Publication date: Available online 7 December 2019Source: Brain, Behavior, and ImmunityAuthor(s): Dániel Kuti, Zsuzsanna Winkler, Krisztina Horváth, Balázs Juhász, Melinda Paholcsek, Anikó Stágel, Gabriella Gulyás, Levente Czeglédi, Szilamér Ferenczi, Krisztina J. KovácsAbstractChronic stress is often accompanied by gastrointestinal symptoms, which might be due to stress-induced shift of gut microbiome to pathogenic bacteria. It has been hypothesized that stress alters gut permeability and results in mild endotoxemia which exaggerates HPA activity and contributes to anxiety and depression. To reveal the relationship between microbiome composition, stress-induced gastrointestinal functions and behavior, we treated chronically stressed mice with non-absorbable antibiotic, rifaximin. The “two hits” stress paradigm was used, where newborn mice were separated from their mothers for 3 hours daily as early life adversity (maternal separation, MS) and exposed to 4 weeks chronic variable stress (CVS) as adults. 16S rRNA based analysis of gut microbiome revealed increases of Bacteroidetes and Proteobacteria and more specifically, Clostridium species in chronically stressed animals. In mice exposed to MS+CVS, we found extenuation of colonic mucosa, increased bacterial translocation to mesenteric lymph node, elevation of plasma LPS levels and infiltration of F4/80 positive macrophages into the colon lamina ...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research

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CONCLUSIONS: Lifestyle subgroups of patients were determined by stress, emotional problems, and age. The groups were significantly associated with Aβ42 and diagnostic outcome. This pattern may confound the differentiation between objective and subjective memory problems. Asking about lifestyle variables, in conjunction with neuropsychological testing, could potentially identify individuals who are not likely to have objective memory impairment and guide interventions. PMID: 31982880 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
Authors: Jain B PMID: 31982311 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
No abstract available
Source: Nursing - Category: Nursing Tags: Department: CLINICAL QUERIES Source Type: research
Britain's healthcare cost agency on Tuesday recommended against including Johnson&Johnson's nasal spray for depression, Spravato, in the country's healthcare network, citing uncertainties over its clinical and cost effectiveness.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
The original version of this article unfortunately contained a mistake. Oliver Hanemann name was incorrect in the in the acknowledgements section of this paper.
Source: Journal of Neurology - Category: Neurology Source Type: research
;di L, Ferenczi S, Kovács KJ Abstract Chronic stress is often accompanied by gastrointestinal symptoms, which might be due to stress-induced shift of gut microbiome to pathogenic bacteria. It has been hypothesized that stress alters gut permeability and results in mild endotoxemia which exaggerates HPA activity and contributes to anxiety and depression. To reveal the relationship between microbiome composition, stress-induced gastrointestinal functions and behavior, we treated chronically stressed mice with non-absorbable antibiotic, rifaximin. The "two hits" stress paradigm was used, where newbor...
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Tags: Brain Behav Immun Source Type: research
In this study, C57BL/6 and Tau KO mice were used. For Tau KO mice, Western blot results of anti-Tau protein specific antibodies showed that Tau KO mice had no positive bands at 50–55 kDa (Tau protein position), while C57BL/6 mice normally expressed Tau protein (Figure 1).FIGURE 1Figure 1 Tau knockout (KO) mice did not express Tau protein.The C57BL/6 mice exhibited depressive behaviors, including anxiety, anhedonia, and depression-like after CUMS, and ketamine treatment alleviated their depressive behavior. Tau KO mice did not exhibit depressive behavior after CUMS. After treatment with ketamine at the same dose, ther...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
In this study, a link between mitochondrial changes and infant temperament has also been suggested. Maternal psychosocial stress and lifetime trauma have been associated with decreased mitochondrial DNA copy number in the placenta (115, 116).IndividualityChronic stress links changes in the epigenetic landscape with health conditions (117). Different cell types are characterized by distinct patterns of gene expression due to developmental, environmental, physiological, and pathological reasons (117). Epigenetic mechanisms affect gene function in a dynamic way as a result of different environmental exposures during fetal dev...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Does Prenatal Stress Shape Postnatal Resilience? – An Epigenome-Wide Study on Violence and Mental Health in Humans Fernanda Serpeloni1,2, Karl M. Radtke1,3, Tobias Hecker4, Johanna Sill1, Vanja Vukojevic5, Simone G. de Assis2, Maggie Schauer1, Thomas Elbert1 and Daniel Nätt6* 1Clinical Psychology and Neuropsychology, Department of Psychology, University of Konstanz, Konstanz, Germany 2Department of Studies in Violence and Health Jorge Careli, National School of Public Health of Rio de Janeiro – National Institute of Women, Children and Adolescents Health Fernandes Figueira, Oswaldo Cruz Foundation, ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
In conclusion, our findings suggest that pregnancy may protect against bacterial translocation, while alcohol use may increase bacterial translocation. The results suggest that end of term mucosa-derived immune responses to Gram-B contribute to immune activation, physio-somatic symptoms at the end of term and postnatal anxiety. PMID: 28403801 [PubMed - as supplied by publisher]
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Tags: CNS Neurol Disord Drug Targets Source Type: research
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