Prognostic factors for renal transplant graft survival in a retrospective cohort of 1000 cases: The role of desensitization therapy

ConclusionHLA mismatches, delayed graft function with or without recovery, and AMR were significant factors for poor graft survival. Detection and desensitization of DSA currently might be inadequate to improve the long-term outcome of renal transplantation.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research

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Neuropathic pain causes severe suffering, and most patients are resistant to current therapies. A core element of neuropathic pain is the loss of inhibitory tone in the spinal cord. Previous studies have shown that foetal GABAergic neuron precursors can provide relief from pain. However, the source of these precursor cells and their multipotent status make them unsuitable for therapeutic use. Here, we extend these findings by showing, for the first time, that spinally transplanted, terminally differentiated human induced pluripotent stem cell-derived GABAergic (iGABAergic) neurons provide significant, long-term, and safe r...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Experts in the Netherlands, Cambridge and London are developing a 'soft robot' heart which could keep blood pumping around the body.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 21 January 2020Source: Plant ScienceAuthor(s): Manuel Méndez-Gómez, Elda Castro-Mercado, César Arturo Peña Uribe, Homero Reyes de la Cruz, José López-Bucio, Ernesto García-PinedaAbstractAzospirillum brasilense colonizes plant roots and improves productivity, but the molecular mechanisms behind its phytostimulation properties remain mostly unknown. Here, we uncover an important role of TARGET OF RAPAMYCIN (TOR) signaling on the response of Arabidopsis thaliana to A. brasilense Sp245. The effect of the bacterium on TOR expression was analyzed...
Source: Plant Science - Category: Biology Source Type: research
ConclusionsHumoral factors from HGF suppressed osteogenesis in MSCs. The effect was regulated by miRNAs and undifferentiated MSC markers. miR-101-3p and ETV1 were the key factors and were regulated by IGF-1.
Source: Journal of Bone and Mineral Metabolism - Category: Orthopaedics Source Type: research
The increasing life expectancy of humans has led to a growing numbers of patients with chronic diseases and end-stage organ failure. Transplantation is an effective approach for the treatment of end-stage organ failure; however, the imbalance between organ supply and the demand for human organs is a bottleneck for clinical transplantation. Therefore, xenotransplantation might be a promising alternative approach to bridge the gap between the supply and demand of organs, tissues, and cells; however, immunological barriers are limiting factors in clinical xenotransplantation. Thanks to advances in gene-editing tools and immun...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Recently, breakthroughs have been made in the use of mesenchymal stem cells (MSCs) to treat various diseases. Several stem cell types have been authorized as drugs by the European Medicines Agency and the U.S. Food and Drug Administration. The Chinese official document “Notification of the management of stem cell clinical research (trial)” was also published in August 2015. Currently, China has approved 106 official stem cell clinical research filing agencies and 62 clinical research projects, which are mostly focused on MSC therapy. Hence, the optimization and development of stem cell drugs is imperative. Duri...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionWe identify iRhom2 as a key regulator that promotes obesity-associated metabolic disorders. Loss of iRhom2 from macrophages in adipose tissues may indirectly restrain inflammation and insulin resistance via blocking crosslink between macrophages and adipocytes. Hence, iRhom2 may be a therapeutic target for obesity-induced metabolic dysfunction.Graphical abstract
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
Condition:   Irritable Bowel Syndrome Intervention:   Dietary Supplement: Feces Sponsors:   Helse Fonna;   University of Bergen Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Cartilage Damage Intervention:   Drug: Instant MSC Product accompanying Autologous Chondron Transplantation Sponsors:   R.J.H. Custers;   ZonMw: The Netherlands Organisation for Health Research and Development Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 22 January 2020Source: Best Practice &Research Clinical AnaesthesiologyAuthor(s): Beatriz Tena, Marina VendrellSummaryKidney transplantation is the treatment of choice in patients with end-stage renal disease, as it improves survival and quality of life. Living donor kidney transplant prior to pancreas transplantation, or simultaneous pancreas and kidney transplantation are also discussed.Patients usually present comorbidities, and extensive preoperative workups are recommended, especially cardiac assessment, though type and frequency of surveillance is not established.Nefroprotective...
Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research
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