Early posttransplant spirometry is associated with the development of bronchiolitis obliterans syndrome after allogeneic hematopoietic cell transplant

Bronchiolitis obliterans syndrome (BOS) is a devastating complication of allogeneic hematopoietic cell transplant (allo-HCT) and is associated with significant morbidity and mortality. BOS is usually not diagnosed until patients present with respiratory symptoms, at which point airflow obstruction is already advanced [1,2]. Detecting an early decline in lung function is challenging as it is often asymptomatic [3,4]. Once established, patients can experience progressive and irreversible respiratory impairment, repeated lung infections, and increased risk of non-relapse mortality [5 –7].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research

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Bronchiolitis obliterans syndrome (BOS) is a devastating complication of allogeneic hematopoietic cell transplantation (allo-HCT), associated with significant morbidity and mortality. BOS is usually not diagnosed until a patient presents with respiratory symptoms, at which point airflow obstruction is already advanced [1,2]. Detecting an early decline in lung function is challenging, because it is often asymptomatic [3,4]. Once established, patients can experience progressive and irreversible respiratory impairment, repeated lung infections, and increased risk of nonrelapse mortality [5-7].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Conclusions: Patients with chronic disease have good outcome in our follow up until 18 years of age.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Idiopathic interstitial pneumonias Source Type: research
Abstract Bronchiolitis obliterans syndrome (BOS) following allogenic haematopoietic stem cell transplant is considered the manifestation of chronic graft versus host disease (cGvHD) in the lung, and affects about 14% of patients with cGvHD, mainly in the first 2 years after transplant. Despite advances in assessment, diagnosis and treatment, the clinical prognosis remains poor for patients with pulmonary manifestations of cGvHD. A pilot study of 50 patients was devised to establish whether a relationship exists between forced expiratory volume in 1 second (FEV1) via pulmonary function test (PFT) and the equivalent...
Source: British Journal of Nursing - Category: Nursing Authors: Tags: Br J Nurs Source Type: research
Objective To evaluate the diagnostic value of function volume/morphological volume ratio calculated from ventilation/perfusion single-photon emission computed tomography/computed tomography in distinguishing the lungs with bronchiolitis obliterans syndrome (BOS) from the lungs without this syndrome after lung transplantation and to assess its relationship with spirometry parameters. Materials and methods We retrospectively identified 84 consecutive lung transplant recipients and 13 donors who underwent ventilation/perfusion single-photon emission computed tomography/computed tomography. Differences in the function vol...
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: ORIGINAL ARTICLES Source Type: research
This study was designed to identify factors associated with clinical response to extracorporeal photopheresis (ECP) and mortality after ECP in lung allograft recipients with bronchiolitis obliterans. Methods. Forced expiratory volume in 1 second (FEV1) values obtained 6 months before (baseline) and 6 months after initiation of ECP were used to plot the linear relationship between FEV1 versus time before and after ECP. Response to ECP was assigned when a positive integer was derived after subtracting the baseline rate of decline from the rate of decline 6 months after ECP. Univariate and multivariate logistic regression ...
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Conclusion: LCI can be successfully measured in LTx patients, and changes with BOS grade. Longitudinal assessments will reveal whether abnormal LCI in those with preserved FEV1 predicts future clinical change.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical respiratory physiology, exercise and functional imaging Source Type: research
Conclusion: In screening pulmonary function studies prior to HSCT in 26 subjects and testing at 2 months post-HSCT in 2 patients, we observed significant correlation of spirometric airflow obstruction with X5 and AX, suggesting that X5 and AX hold promise for early detection of airflow obstruction post-HSCT.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
CONCLUSION: LR is a therapeutic option in selected patients with CLAD, with acceptable survival. Indication for LR early after LT shows poor outcomes. PMID: 30131203 [PubMed - as supplied by publisher]
Source: Archivos de Bronconeumologia - Category: Respiratory Medicine Authors: Tags: Arch Bronconeumol Source Type: research
We present here the incidence and long-term outcome of BOS occurring after HSCT in an extended cohort of 110 patients monitored with home spirometry.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research
Background: Bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic cell transplant (HCT), a manifestation of chronic graft-versus-host disease, may occur insidiously and remain asymptomatic until significant loss of lung function has occurred. Early diagnosis and intervention are needed to prevent the morbidity and mortality associated with BOS, however screening strategies such as frequent spirometry are difficult to universally implement. The aim of this study was to assess which readily available clinical factors, with an emphasis on pulmonary function test (PFT) parameters, can identify patients at risk...
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
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