Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population

ConclusionABCB1 C3435T and ABCG2 C421A might represent a potential risk factor for breast cancer for Turkish women.
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research

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Publication date: Available online 17 January 2020Source: European Journal of RadiologyAuthor(s): Soo Jeong Lee, Kyung Hee Ko, Hae Kyoung Jung, Ji Eun Koh, Ah Young ParkAbstractPurposeTo investigate whether the additional use of ultrafast MRI can improve the diagnostic performance of conventional dynamic contrast-enhanced MRI (DCE-MRI) in evaluating MRI-detected lesions in breast cancer patients.MethodsThis retrospective study enrolled 101 consecutive breast cancer patients with 202 breast lesions (62 benign and 140 malignant) who underwent preoperative DCE-MRI with ultrafast imaging (9 image sets with 6.5-second temporal ...
Source: European Journal of Radiology - Category: Radiology Source Type: research
In this study, we assessed the impact of interacting medication and pharmacogenetic variation to better explain apixaban concentration differences among 358 Caucasian AF patients. Genotyping (ABCG2,ABCB1,CYP3A4*22,CYP3A5*3) was performed by TaqMan assays, and apixaban quantified by mass spectrometry. The typical patient was on average 77.2  years old, 85.5 kg, and had a serum creatinine of 103.1 µmol/L. Concomitant amiodarone, an antiarrhythmic agent and moderate CYP3A/ABCB1 inhibitor, the impaired-function variantABCG2 c.421C  >  A, and sex predicted higher apixaban concentrations whe...
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
No abstract available
Source: Oncology Times - Category: Cancer & Oncology Tags: News Source Type: research
A group of former patients of Raleigh Radiology filed a  lawsuitthis month against the imaging center for producing substandard mammograms and not meeting American College of Radiology (ACR) standards. Lawyers of plaintiff Emily Cram, a Wake County resident, filed the December 31 suit on her behalf. Cram had undergone three mammograms at Raleigh Radiology ’s Blue Ridge location between November 7, 2017 and November 6, 2019, a period of time of which the ACR stated in a review that the clinic didn’t meet their imaging standards. After the ACR review, the center was mandated to inform all patients that mammo...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
l A. El-Sayed New thienyl- or chlorophenyl-substituted thiazolopyrimidine derivatives and their derived sugar hydrazones incorporating acyclic d-galactosyl or d-xylosyl sugar moieties in addition to their per-O-acetylated derivatives were synthesized. Heterocyclization of the formed sugar hydrazones afforded the derived acyclic nucleoside analogues possessing the 1,3,4-oxadiazoline as modified nucleobase via acetylation followed by the cyclization process. The cytotoxic activity of the synthesized compounds was studied against human breast cancer MCF7 and MDA-MB-231 cell lines as well as human colorectal cancer HCT 116...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
ConclusionEven though the number of cases was low, slight indications of an inverse association between coffee consumption and breast cancer risk among postmenopausal women were observed. Further longitudinal studies are warranted to confirm this finding.
Source: European Journal of Nutrition - Category: Nutrition Source Type: research
FRIDAY, Jan. 17, 2020 -- Minority women with breast cancer are less likely to have insurance, which could lower their odds of survival, researchers say. " Having adequate health insurance for all could reduce the persistent racial outcome disparities...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
This study demonstrates a comprehensive and cost-effectively scalable one-step rapid bio-fabrication of Eucalyptus globulus leaf extract (ELE) bio-actives functionalized copper oxide nanoparticles (CuONPs) against human breast cancer (MCF-7) cells and Aspergillus flavus. The state-of-art characterization confirmed the thermal-stability of (i) ELE-CuONPs and (ii) surface associated ELE bio-active compounds bearing characteristic functional groups (aromatic-OH, polymeric-OH, C-O, and C = O) over a range of conventional temperatures (30 °C to 80 °C) and microwave (MW) heat (140 °...
Source: Process Biochemistry - Category: Biochemistry Source Type: research
DNA changes in a common type of breast cancer cell may be linked to hormone therapy resistance, according to a study published inNature Communications.Science Daily
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
CONCLUSIONS BORG promotes the development of chemoresistance of CRC cells to carboplatin. PMID: 31937750 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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