Mucoadhesive buccal film of almotriptan improved therapeutic delivery in rabbit model

Publication date: Available online 7 December 2019Source: Saudi Pharmaceutical JournalAuthor(s): Anroop B. Nair, Bandar E. Al-Dhubiab, Jigar Shah, Shery Jacob, Saraiya Vismay, Mahesh Attimarad, Nagaraja SreeHarsha, Sabah H. Akrawi, Tamer M. ShehataAbstractAdministration of almotriptan as an oral therapy is largely limited because of poor aqueous solubility and rather low bioavailability. The aim of present investigation was to formulate oral mucoadhesive film of almotriptan to improve the drug delivery and desired therapeutic effects. Placebo films (F1-F8) were prepared by varying the concentrations of Proloc 15 (7.5% w/v-15% w/v) and Eudragit RL 100/ RS 100 (15% w/v-30% w/v) polymers. Physicomechanical and pharmaceutical characteristics of drug loaded films (FA1-FA4) were examined. Selected FA4 film was evaluated in vivo by assessing the pharmacokinetic profile and compared with oral therapy in rabbits. FA1-FA4 films exhibited excellent physicomechanical properties and rapid hydration. A biphasic and considerably greater drug release (p
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research

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Conclusion: Congenital polycythemia was clinically diagnosed, mimicking Chuvash polycythemia. Chuvash polycythemia is an autosomal recessive disorder that usually harbors a homozygous mutation of VHL598C>T but not predispose to pheochromocytoma development; in contrast our patient showed for the first time that the concurrent heterozygous VHL and TMEM mutations, resulted in a clinical phenotype of a normotensive patient with polycythemia due to erythropoietin-secreting pheochromocytoma that improved after adrenalectomy.
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Secondary hypertension Source Type: research
ConclusionThe pooled estimated prevalence of headache among patients with epilepsy was considerably high (48.4%). Screening and appropriate management of headaches among patients with epilepsy are warranted.
Source: The Journal of Headache and Pain - Category: Neurology Source Type: research
Abstract OBJECTIVE: To provide updated evidence-based recommendations about when to obtain neuroimaging in patients with migraine. METHODS: Articles were included in the systematic review if they studied adults 18 and over who were seeking outpatient treatment for any type of migraine and who underwent neuroimaging (MRI or CT). Medline, Web of Science, and Cochrane Clinical Trials were searched from 1973 to August 31, 2018. Reviewers identified studies, extracted data, and assessed the quality of the evidence in duplicate. We assessed study quality using the Newcastle-Ottawa Scale. RESULTS: The initial s...
Source: Headache - Category: Neurology Authors: Tags: Headache Source Type: research
Conclusions: Health complaints are frequent but unequally distributed across family structures. Adolescents in nuclear families and JPC report lower levels of health complaints compared to peers in single- or stepparent families. Considering siblings appears to be relevant, as biological- and stepsiblings were related to adolescents' symptoms, independent of family structure. In combination, knowledge about family structure and sibship-type may aid the identification of adolescents at risk of experiencing health complaints. PMID: 31830876 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Public Health - Category: International Medicine & Public Health Authors: Tags: Scand J Public Health Source Type: research
Publication date: November 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 11Author(s): Mei-Qi WAN, You-Bo ZHANG, Xiao-Yan LIU, Ke-Ming LI, Ling-Yun JIA, Xiu-Wei YANGAbstractAngelicae Pubescentis Radix (APR), a widely used traditional Chinese medicine (TCM), is mainly used to treat rheumatism and headache diseases. Angelol B is one of the bioactive constituents of APR with significant anti-inflammatory activity. This paper is aimed to illustrate the metabolites of angelol B in vivo. To achieve this objective, a metabolomics approach based on a rapid and accurate UPLC-Q-TOF-MS method was used to detect th...
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research
ConclusionThe association of PA and RCC is extremely rare. On MRI, they appear as a solid-cystic or cystic sellar tumors. RCC can rupture causing granulomatous reaction with cholesterol crystal formation, which can be mistaken for craniopharyngiomas during surgery. Therefore, collision sellar lesion must be included in the differential diagnosis of cystic sellar lesions. The definitive diagnosis is made by histological study.
Source: Endocrine - Category: Endocrinology Source Type: research
ConclusionThese findings indicate that cortical GABA levels are normal in patients suffering from relatively few migraine attacks. Previous studies have reported that cortical GABA in patients with more frequent migraines is reduced; further investigation of the inhibitory system in migraine patients is warranted to determine the underlying mechanisms.
Source: The Journal of Headache and Pain - Category: Neurology Source Type: research
Do I still have a blog? You wouldn’t know it by how infrequently I’ve updated it lately. Sometimes life can overwhelm. When that happens, I like to believe that I will always be plucky enough to fend off the doldrums and shake my fist defiantly at the obstacles that beset me. However, when illness weakens your knees and keeps you motionless in bed, is there enough pluck to lift your fist, never mind keep your spirits up?I ’ve been incredibly sick this Fall. I started my journey on September 7th. I attended FanX in Salt Lake City, had a good time attending with my daughter, then came home and tried to figh...
Source: The Splintered Mind by Douglas Cootey - Category: Psychiatry Tags: Depression Goodreads Journaling Somnambulating Source Type: blogs
Conclusions Despite being a rare condition, Gradenigo syndrome should be taken into account as potential differential diagnosis in children referred to emergency department for recurrent headache and strabismus. An accurate anamnesis to document recent ear infection is mandatory to orientate the diagnosis and focus radiological investigations. Early recognition and timely intervention may allow conservative management to succeed, avoiding the need for surgery and serious sequelae.
Source: Pediatric Emergency Care - Category: Emergency Medicine Tags: Illustrative Cases Source Type: research
Conclusion: GKS is an acceptable salvage treatment option for patients with recurrent NPC who previously received radiation therapy. PET-CT and MRI co-registration for dose planning can help achieve local control of recurrent NPC. PMID: 31775216 [PubMed - as supplied by publisher]
Source: Journal of Korean Neurosurgical Society - Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research
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