Mucoadhesive buccal film of almotriptan improved therapeutic delivery in rabbit model

Publication date: Available online 7 December 2019Source: Saudi Pharmaceutical JournalAuthor(s): Anroop B. Nair, Bandar E. Al-Dhubiab, Jigar Shah, Shery Jacob, Saraiya Vismay, Mahesh Attimarad, Nagaraja SreeHarsha, Sabah H. Akrawi, Tamer M. ShehataAbstractAdministration of almotriptan as an oral therapy is largely limited because of poor aqueous solubility and rather low bioavailability. The aim of present investigation was to formulate oral mucoadhesive film of almotriptan to improve the drug delivery and desired therapeutic effects. Placebo films (F1-F8) were prepared by varying the concentrations of Proloc 15 (7.5% w/v-15% w/v) and Eudragit RL 100/ RS 100 (15% w/v-30% w/v) polymers. Physicomechanical and pharmaceutical characteristics of drug loaded films (FA1-FA4) were examined. Selected FA4 film was evaluated in vivo by assessing the pharmacokinetic profile and compared with oral therapy in rabbits. FA1-FA4 films exhibited excellent physicomechanical properties and rapid hydration. A biphasic and considerably greater drug release (p<0.05) was observed in FA3 and FA4 films contain higher amount of hydrophilic polymer. The rate of permeation of almotriptan was found to be significantly higher in FA4 than FA3 film (p<0.005). Fourier transform infrared spectral scan indicates no incompatibility exists between the drug and polymers used. Differential scanning calorimetry thermogram represents the evidence of almotriptan amorphization and molecular dispersion of it in ...
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research