Functional coupling of M1 muscarinic acetylcholine receptor to G αq/11 in dorsolateral prefrontal cortex from patients with psychiatric disorders: a postmortem study.

Functional coupling of M1 muscarinic acetylcholine receptor to Gαq/11 in dorsolateral prefrontal cortex from patients with psychiatric disorders: a postmortem study. Eur Arch Psychiatry Clin Neurosci. 2019 Dec 05;: Authors: Odagaki Y, Kinoshita M, Meana JJ, Callado LF, García-Sevilla JA Abstract Accumulating studies have implicated intracellular signaling through muscarinic acetylcholine receptors (mAChRs) in psychiatric illness. In the present study, carbamylcholine chloride (carbachol)-induced Gαi/o and Gαq/11 activation was identified in postmortem human prefrontal cortical membranes. The following two sample cohorts were used: subjects [1], consisting of 40 controls without neuropsychiatric disorders, and subjects [2], consisting of 20 with bipolar disorder (BP), 20 major depressive disorder (MDD), 20 schizophrenia, and 20 controls, strictly sex- and age-matched. Carbachol-stimulated [35S]GTPγS binding to human brain membranes was assessed by the two methods, i.e., conventional method using filtration techniques (Gαi/o activation coupled to M2/M4 mAChRs) applied to subjects [1], and [35S]GTPγS binding/immuno precipitation assay (Gαq/11 activation coupled to M1 mAChR) applied to subjects [1] and [2]. The concentration eliciting the half-maximal effect (EC50), maximum percent increase (%Emax), and slope factor were obtained from concentration-response curve of carbachol-induced Gαi/o and Gαq/1...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

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Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
ConclusionPsychotropic medication non-adherence was high. It was influenced by various factors operating at different levels. Therefore, comprehensive intervention strategies should be designed to address factors associated with psychotropic medication non-adherence.Systematic review registrationPROSPERO CRD42017067436
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
Astudy appearing today inJAMA Psychiatry found that fewer than 7% of patients with psychiatric disorders in Sweden had either been subjected to violence severe enough to require specialist medical treatment or had perpetrated violence.Amir Sariaslan, Ph.D., of the University of Oxford and colleagues identified 250,419 individuals from Sweden ’s National Patient Register who were born between 1973 and 1993 and had been diagnosed psychiatric disorders. Psychiatric disorders included anxiety disorders, depression, bipolar disorder, schizophrenia, personality disorders, alcohol use disorder, and drug use disorder. The pa...
Source: Psychiatr News - Category: Psychiatry Tags: Amir Sariaslan anxiety bipolar disorder depression JAMA Psychiatry Paul Appelbaum personality disorders schizophrenia substance use disorder violence Source Type: research
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Source: Neuroscience Letters - Category: Neuroscience Source Type: research
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar Disorders General Not Crazy Podcast Relationships Sexuality Source Type: blogs
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Source: World Psychiatry - Category: Psychiatry Authors: Tags: World Psychiatry Source Type: research
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Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
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Source: The American Journal of Psychiatry - Category: Psychiatry Authors: Tags: Am J Psychiatry Source Type: research
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Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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Source: Journal of Counseling and Development - Category: Psychiatry & Psychology Authors: Tags: Research Source Type: research
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